Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade c isolate from Africa: Evidence of intraclade recombination

被引：31

作者：

Grisson, RD

Chenine, AL

Yeh, LY

He, J

Wood, C

Bhat, GJ

Xu, WD

Kankasa, C

Ruprecht, RM

机构：

[1] Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Harvard Univ, Med Ctr, Dept Med, Boston, MA 02115 USA

[3] Univ Nebraska, Nebraska Ctr Virol, Lincoln, NE USA

[4] Univ Nebraska, Sch Biol Sci, Lincoln, NE USA

[5] Univ Teaching Hosp, Dept Pediat, Lusaka, Zambia

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 24期

关键词：

D O I：

10.1128/JVI.78.24.14066-14069.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Although human immunodeficiency virus type 1 (HIV-1) clade C continues to dominate the pandemic, only two infectious clade C proviral DNA clones have been described (N. Mochizuki, N. Otsuka, K. Matsuo, T. Shiino, A. Kojima, T. Kurata, K. Sakai, N. Yamamoto, S. Isomura, T. N. Dhole, Y. Takebe, M. Matsuda, and M. Tatsumi, AIDS Res. Hum. Retrovir. 15:1321-1324, 1999; T. Ndung'u, B. Renjifo, and M. Essex, J. Virol. 75:4964-4972, 2001). We have generated an infectious molecular clone of a pediatric clade C strain, HIV1084i, which was isolated from a Zambian infant infected either intrapartum or through breastfeeding. HIV1084i is an R5, non-syncytium-inducing isolate that bears all known clade C signatures; gag, pol, and env consistently mapped within clade C. Interestingly, gag resembled Asian isolates, whereas pol and env resembled African isolates, indicating that HIIV1084i probably arose from an intraclade recombination. As a recently transmitted clade C strain, HIV1084i will be a useful vaccine development tool.

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页码：14066 / 14069

页数：4

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