Mapping genes located on human chromosomes 2 and 12 to porcine chromosomes 15 and 5

被引：7

作者：

Rohrer, GA ^{[1
]}

Alexander, LJ ^{[1
]}

Beattie, CW ^{[1
]}

机构：

[1] USDA ARS, Meat Anim Res Ctr, Clay Ctr, NE 68933 USA

来源：

ANIMAL GENETICS | 1997年 / 28卷 / 06期

关键词：

comparative map; human; pig;

D O I：

10.1111/j.1365-2052.1997.00203.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Informative microsatellites associated with two genes on HSA12 (lysozyme, LYZ; tumour necrosis factor receptor, TNFR) and one gene on HSA2 (glutamic acid decarboxylase 1, GAD1) were mapped in the US Meat Animal Research Center (MARC) swine reference population and the physical assignment of a-lactalbumin (LALBA) was determined. A comparative map for HSA2 and HSA12 with SSC15 and SSC5, respectively, was developed by combining the results from this study with published type I loci mapped in both species. One rearrangement between HSA2 and SSC15 was detected while the number of rearrangements between HSA12 and SSC5 were numerous. These results indicated that conservation of synteny does not imply a conservation of gene order and that additional type I markers need to be mapped in the pig to fully understand the chromosomal rearrangements that occurred during the evolution of mammals.

引用

页码：448 / 450

页数：3

共 17 条

[1] Physical assignments of 68 porcine cosmid and lambda clones containing polymorphic microsatellites [J].