miRNA profiling for diagnosis and prognosis of human cancer

被引:182
作者
Jay, Chris
Nemunaitis, John
Chen, Patrick
Fulgham, Pat
Tong, Alex W.
机构
[1] Baylor Univ, Inst Biomed Studies, Waco, TX USA
[2] Presbyterian Med Ctr, Dallas, TX USA
[3] Murex Pharmaceut, Dallas, TX USA
[4] Mary Crowley Med Res Ctr, Dallas, TX USA
关键词
D O I
10.1089/dna.2006.0554
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
MicroRNAs (miRNAs) are a recently discovered class of small (similar to 18-24 nt) nucleic acids that negatively regulate gene expression. This novel class of molecules modulates a wide array of growth and differentiation processes in human cancers. High throughput analyses, utilizing the solid phase, array platform, or liquid phase, bead-based hybridization have variously demonstrated that miRNA expression was commonly dysregulated in human cancer. miRNA expression profiling has shown promise in defining malignant status in retrospective studies. Considerable disagreement remains with respect to the miRNA signature for a specific cancer cell type, which appears to depend largely on the analytical platform. Nonetheless, various internally controlled studies have successfully identified the histotype of tumors of unknown origin according to miRNA expression profile. The evaluation of miRNAs expression may also be of prognostic value, as best exemplified by the correlation of let-7 and mir-155 levels with disease survival in nonsmall cell lung cancer.
引用
收藏
页码:293 / 300
页数:8
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