Pathogen recognition receptors, cancer and inflammation in the gut

被引:69
作者
Fukata, Masayuki [1 ]
Abreu, Maria T. [1 ]
机构
[1] Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA
基金
美国国家卫生研究院;
关键词
TOLL-LIKE RECEPTOR-4; INTESTINAL EPITHELIAL-CELLS; PROPRIA DENDRITIC CELLS; COLORECTAL-CANCER; CROHNS-DISEASE; ANTICANCER CHEMOTHERAPY; BACTERIAL FLAGELLIN; FRAMESHIFT MUTATION; GENE POLYMORPHISMS; GASTRIC-CARCINOMA;
D O I
10.1016/j.coph.2009.09.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pathogen recognition receptors (PRRs) initiate immediate responses against infection and tissue damage to protect the host from microbial invasion. In response to mucosal damage, intestinal PRR signaling initiates damage repair processes. Recent advances appear to link PRR abnormalities and inflammatory as well as neoplastic intestinal disorders. Emerging evidence suggests a dual role of PRRs, in which they may simultaneously induce tumorigenesis and antitumor immunity. PRR may induce tumor cell proliferation by activating cell survival signaling mainly via NF-kappa B, but this signal can activate dendritic cells to promote antitumor immunity. TLR signaling within the tumor cells may result in evasion of immune surveillance, propagation of metastatic growth, or rather, induction of tumor cell apoptosis depending on ligands. Epithelial cells induce endogenous PRR ligands when damaged or during neoplastic transformation. Targeted manipulation of PRR signaling may provide emerging opportunities for the development of new therapeutic strategies for many gastrointestinal diseases.
引用
收藏
页码:680 / 687
页数:8
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