共 93 条
Pathogen recognition receptors, cancer and inflammation in the gut
被引:69
作者:

Fukata, Masayuki
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA

Abreu, Maria T.
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h-index: 0
机构:
Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA
机构:
[1] Univ Miami, Miller Sch Med, Dept Med, Div Gastroenterol, Miami, FL 33136 USA
基金:
美国国家卫生研究院;
关键词:
TOLL-LIKE RECEPTOR-4;
INTESTINAL EPITHELIAL-CELLS;
PROPRIA DENDRITIC CELLS;
COLORECTAL-CANCER;
CROHNS-DISEASE;
ANTICANCER CHEMOTHERAPY;
BACTERIAL FLAGELLIN;
FRAMESHIFT MUTATION;
GENE POLYMORPHISMS;
GASTRIC-CARCINOMA;
D O I:
10.1016/j.coph.2009.09.006
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The pathogen recognition receptors (PRRs) initiate immediate responses against infection and tissue damage to protect the host from microbial invasion. In response to mucosal damage, intestinal PRR signaling initiates damage repair processes. Recent advances appear to link PRR abnormalities and inflammatory as well as neoplastic intestinal disorders. Emerging evidence suggests a dual role of PRRs, in which they may simultaneously induce tumorigenesis and antitumor immunity. PRR may induce tumor cell proliferation by activating cell survival signaling mainly via NF-kappa B, but this signal can activate dendritic cells to promote antitumor immunity. TLR signaling within the tumor cells may result in evasion of immune surveillance, propagation of metastatic growth, or rather, induction of tumor cell apoptosis depending on ligands. Epithelial cells induce endogenous PRR ligands when damaged or during neoplastic transformation. Targeted manipulation of PRR signaling may provide emerging opportunities for the development of new therapeutic strategies for many gastrointestinal diseases.
引用
收藏
页码:680 / 687
页数:8
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共 93 条
[61]
Role of Nod2 in the response of macrophages to Toll-like receptor agonists
[J].
Pauleau, AL
;
Murray, PJ
.
MOLECULAR AND CELLULAR BIOLOGY,
2003, 23 (21)
:7531-7539

Pauleau, AL
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

Murray, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[62]
Toll-like receptor-1,-2, and-6 polymorphisms influence disease extension in inflammatory bowel diseases
[J].
Pierik, M
;
Joossens, S
;
Van Steen, K
;
Van Schuerbeek, N
;
Vlietinck, R
;
Rutgeerts, P
;
Vermeire, S
.
INFLAMMATORY BOWEL DISEASES,
2006, 12 (01)
:1-8

Pierik, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Joossens, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Van Steen, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Van Schuerbeek, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Vlietinck, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Rutgeerts, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium

Vermeire, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Internal Med Gastroenterol, B-3000 Louvain, Belgium
[63]
5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
[J].
Poeck, Hendrik
;
Besch, Robert
;
Maihoefer, Cornelius
;
Renn, Marcel
;
Tormo, Damia
;
Morskaya, Svetlana Shulga
;
Kirschnek, Susanne
;
Gaffal, Evelyn
;
Landsberg, Jennifer
;
Hellmuth, Johannes
;
Schmidt, Andreas
;
Anz, David
;
Bscheider, Michael
;
Schwerd, Tobias
;
Berking, Carola
;
Bourquin, Carole
;
Kalinke, Ulrich
;
Kremmer, Elisabeth
;
Kato, Hiroki
;
Akira, Shizuo
;
Meyers, Rachel
;
Haecker, Georg
;
Neuenhahn, Michael
;
Busch, Dirk
;
Ruland, Juergen
;
Rothenfusser, Simon
;
Prinz, Marco
;
Hornung, Veit
;
Endres, Stefan
;
Tueting, Thomas
;
Hartmann, Gunther
.
NATURE MEDICINE,
2008, 14 (11)
:1256-1263

Poeck, Hendrik
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, D-53127 Bonn, Germany
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Besch, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Dermatol & Allergol, D-80337 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Maihoefer, Cornelius
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Renn, Marcel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Tormo, Damia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Morskaya, Svetlana Shulga
论文数: 0 引用数: 0
h-index: 0
机构:
Alnylam Pharmaceut, Cambridge, MA 02142 USA Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Kirschnek, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Gaffal, Evelyn
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Landsberg, Jennifer
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Hellmuth, Johannes
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, D-53127 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Schmidt, Andreas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Anz, David
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Bscheider, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Schwerd, Tobias
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Berking, Carola
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Dermatol & Allergol, D-80337 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Bourquin, Carole
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Kalinke, Ulrich
论文数: 0 引用数: 0
h-index: 0
机构:
Paul Ehrlich Inst, Div Immunol, D-63225 Langen, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Kremmer, Elisabeth
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Helmholtz Zentrum Munchen, Inst Mol Immunol, D-81377 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Kato, Hiroki
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Akira, Shizuo
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Res Inst Microbial Dis, Dept Host Def, Suita, Osaka 5650871, Japan Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Meyers, Rachel
论文数: 0 引用数: 0
h-index: 0
机构:
Alnylam Pharmaceut, Cambridge, MA 02142 USA Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Haecker, Georg
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Neuenhahn, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Busch, Dirk
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Ruland, Juergen
论文数: 0 引用数: 0
h-index: 0
机构:
Tech Univ Munich, Klinikum Rechts Isar, Med Klin 3, D-81675 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Rothenfusser, Simon
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Prinz, Marco
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Dept Neuropathol, D-79106 Freiburg, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Hornung, Veit
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, D-53127 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Endres, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Munich, Dept Internal Med, Div Clin Pharmacol, D-80336 Munich, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Tueting, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany

Hartmann, Gunther
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bonn, Univ Hosp, Inst Clin Chem & Pharmacol, D-53127 Bonn, Germany Univ Bonn, Dept Dermatol & Allergol, Lab Expt Dermatol, D-53105 Bonn, Germany
[64]
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
[J].
Rakoff-Nahoum, S
;
Paglino, J
;
Eslami-Varzaneh, F
;
Edberg, S
;
Medzhitov, R
.
CELL,
2004, 118 (02)
:229-241

Rakoff-Nahoum, S
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Paglino, J
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Eslami-Varzaneh, F
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Edberg, S
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

Medzhitov, R
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA
[65]
Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
[J].
Rakoff-Nahoum, Seth
;
Medzhitov, Ruslan
.
SCIENCE,
2007, 317 (5834)
:124-127

Rakoff-Nahoum, Seth
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA

Medzhitov, Ruslan
论文数: 0 引用数: 0
h-index: 0
机构: Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA
[66]
Lamina propria dendritic cells: For whom the bell TOLLs?
[J].
Rescigno, Maria
;
Matteoli, Gianluca
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2008, 38 (06)
:1483-1486

Rescigno, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy

Matteoli, Gianluca
论文数: 0 引用数: 0
h-index: 0
机构:
European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy
[67]
Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer
[J].
Rhee, Sang Hoon
;
Im, Eunok
;
Pothoulakis, Charalabos
.
GASTROENTEROLOGY,
2008, 135 (02)
:518-528

Rhee, Sang Hoon
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Gastroenterol, Boston, MA 02215 USA Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA

Im, Eunok
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA

Pothoulakis, Charalabos
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA
Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Gastroenterol, Boston, MA 02215 USA Univ Calif Los Angeles, David Geffen Sch Med, Div Digest Dis, Ctr Inflammatory Bowel Dis, Los Angeles, CA 90095 USA
[68]
A family of human receptors structurally related to Drosophila Toll
[J].
Rock, FL
;
Hardiman, G
;
Timans, JC
;
Kastelein, RA
;
Bazan, JF
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1998, 95 (02)
:588-593

Rock, FL
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA

Hardiman, G
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA

Timans, JC
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA

Kastelein, RA
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA

Bazan, JF
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Mol Biol, Prot Machine Grp, Palo Alto, CA 94304 USA
[69]
Safety, pharmacokinetics, pharmaoodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers
[J].
Rossignol, DP
;
Wasan, MM
;
Choo, E
;
Yau, E
;
Wong, N
;
Rose, J
;
Moran, J
;
Lynn, M
.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,
2004, 48 (09)
:3233-3240

Rossignol, DP
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Wasan, MM
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Choo, E
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Yau, E
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Wong, N
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Rose, J
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Moran, J
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA

Lynn, M
论文数: 0 引用数: 0
h-index: 0
机构: Eisai Med Res Inc, Teaneck, NJ 07666 USA
[70]
Toll-like receptor 3 expressed by melanoma cells as a target for therapy?
[J].
Salaun, Bruno
;
Lebecque, Serge
;
Matikainen, Sampsa
;
Rimoldi, Donata
;
Romero, Pedro
.
CLINICAL CANCER RESEARCH,
2007, 13 (15)
:4565-4574

Salaun, Bruno
论文数: 0 引用数: 0
h-index: 0
机构: Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

Lebecque, Serge
论文数: 0 引用数: 0
h-index: 0
机构: Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

Matikainen, Sampsa
论文数: 0 引用数: 0
h-index: 0
机构: Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

Rimoldi, Donata
论文数: 0 引用数: 0
h-index: 0
机构: Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland

Romero, Pedro
论文数: 0 引用数: 0
h-index: 0
机构: Ludwig Inst Canc Res, CH-1066 Epalinges, Switzerland