Synthesis of β-substituted alanines via Michael addition of nucleophiles to dehydroalanine derivatives

被引：36

作者：

Ferreira, PMT ^{[1
]}

Maia, HLS ^{[1
]}

Monteiro, LS ^{[1
]}

Sacramento, J ^{[1
]}

Sebastiao, J ^{[1
]}

机构：

[1] Univ Minho, Dept Chem, P-4700320 Braga, Portugal

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 19期

关键词：

D O I：

10.1039/b003353g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several beta-substituted alanines are synthesised in high yields by a Michael addition of nucleophiles to N-acyl-N-(tert-butoxycarbonyl)dehydroalanine methyl ester, using mild reaction conditions and simple work-up procedures. The same method can be applied to dipeptides containing dehydroalanine.

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收藏

页码：3317 / 3324

页数：8

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