Signaling kinases modulated by 4-hydroxynonenal

被引：117

作者：

Leonarduzzi, G ^{[1
]}

Robbesyn, F ^{[1
]}

Poli, G ^{[1
]}

机构：

[1] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, I-10043 Turin, Italy

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2004年 / 37卷 / 11期

关键词：

4-hydroxynonenal; cell signaling; protein kinase C; MAP kinases; tyrosine kinases; free radicals;

D O I：

10.1016/j.freeradbiomed.2004.08.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interaction of 4-hydroxynonenal (HNE) with a variety of kinases variously involved in cell signaling is now a matter of active investigation. In particular, findings with regard to the effect of HNE on different components of the protein kinase C family and the mitogen-activated protein kinase complex already provide reliable indications of a potential role of this aldehyde as a cell signal messenger. Such a role appears further supported by the clear-cut evidence of up-regulation of receptor tyrosine kinases and down-regulation of the nuclear factor kappa B system, produced by FINE concentrations actually detectable in pathophysiology. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1694 / 1702

页数：9

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