A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

被引：277

作者：

Lefebvre, Celine ^{[1
,2
,3
]}

Rajbhandari, Presha ^{[1
,2
,3
]}

Alvarez, Mariano J. ^{[1
,2
,3
]}

Bandaru, Pradeep ^{[1
,2
,3
]}

Lim, Wei Keat ^{[1
,4
]}

Sato, Mai ^{[5
,6
]}

Wang, Kai ^{[1
,4
]}

Sumazin, Pavel ^{[1
,2
,3
]}

Kustagi, Manjunath ^{[1
,2
,3
]}

Bisikirska, Brygida C. ^{[1
,2
,3
]}

Basso, Katia ^{[5
,6
]}

Beltrao, Pedro ^{[7
]}

Krogan, Nevan ^{[7
]}

Gautier, Jean ^{[5
,6
]}

Dalla-Favera, Riccardo ^{[5
,6
,8
,9
]}

Califano, Andrea ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Columbia Univ, Ctr Computat Biol & Bioinformat, New York, NY 10032 USA

[2] Columbia Univ, Joint Ctr Syst Biol, New York, NY 10032 USA

[3] Columbia Univ, Columbia Initiat Syst Biol, New York, NY 10032 USA

[4] Columbia Univ, Dept Biomed Informat, New York, NY 10032 USA

[5] Columbia Univ, Inst Canc Genet, New York, NY 10032 USA

[6] Columbia Univ, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

[7] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA

[8] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

[9] Columbia Univ, Dept Genet & Dev, New York, NY 10032 USA

来源：

MOLECULAR SYSTEMS BIOLOGY | 2010年 / 6卷

关键词：

B cell; germinal centers; interactome; master regulator; PROTEIN-PROTEIN INTERACTIONS; TRANSCRIPTIONAL NETWORK; BIOLOGY APPROACH; C-MYC; DNA; MODULATORS; ONCOGENES; REVEALS; BINDING; SYSTEMS;

D O I：

10.1038/msb.2010.31

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Assembly of a transcriptional and post-translational molecular interaction network in B cells, the human B-cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre-replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues. Molecular Systems Biology 377; published online 8 June 2010; doi:10.1038/msb.2010.31

引用

页数：10

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