Benzylisoquinoline alkaloids from the tubers of Corydalis ternata and their cytotoxicity

被引：39

作者：

Kim, Ki Hyun ^{[1
]}

Lee, Il Kyun ^{[1
]}

Piao, Cheng Jie ^{[1
]}

Choi, Sang Un ^{[2
]}

Lee, Jei Hyun ^{[3
]}

Kim, Yeong Shik ^{[4
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Nat Prod Lab, Sch Pharm, Suwon 440746, South Korea

[2] Korea Res Inst Chem Technol, Taejon 305600, South Korea

[3] Dongguk Univ, Coll Oriental Med, Gyeong Ju 780714, South Korea

[4] Seoul Natl Univ, Inst Nat Prod Res, Coll Pharm, Seoul 151742, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期

关键词：

Corydalis ternate; Papaveraceae; Benzylisoquinoline alkaloids; Cytotoxicity; ISOQUINOLINE ALKALOIDS; DL-TETRAHYDROPALMATINE; CONSTITUENTS; GLYCOSIDES; PLANT; SEEDS; ACID; H-1;

D O I：

10.1016/j.bmcl.2010.06.035

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigation of the tubers of Corydalis ternata resulted in the isolation and characterization of four new benzylisoquinoline alkaloids, epi-coryximine (1) and coryternatines A-C (2-4), along with 10 known alkaloids (5-14). Their structures were established on the basis of extensive spectroscopic data analyses and comparison with spectroscopic data reported. In addition, the cytotoxicities of the alkaloids (1-14) were evaluated by determining their inhibitory effects on several human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) using the SRB assay. Compound 8 showed significant cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines (IC50 = 8.34, 5.14, 7.87, and 2.86 mu M, respectively). The four new compounds (1-4) exhibited selective cytotoxicity against the HCT-15 cell line. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：4487 / 4490

页数：4

共 29 条

[1] 2 METHYLENEDIOXY BRIDGE FORMING CYTOCHROME-P-450 DEPENDENT ENZYMES ARE INVOLVED IN (S)-STYLOPINE BIOSYNTHESIS [J].