Effects of LPS and IL-6 on oxytocin receptor in non-pregnant and pregnant rat uterus

被引：43

作者：

Fang, X ^{[1
]}

Wong, S ^{[1
]}

Mitchell, BF ^{[1
]}

机构：

[1] Univ Alberta, Dept Obstet & Gynecol, Perinatal Res Ctr, Edmonton, AB T5H 3V9, Canada

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2000年 / 44卷 / 02期

关键词：

cytokines; estrogen; parturition; progesterone;

D O I：

10.1111/j.8755-8920.2000.440201.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

PROBLEM: Little is known regarding the regulation of the timing of parturition. Recent evidence suggests an interaction between the immune system and uterine contractility in late gestation. METHOD: Pregnant rats were treated with LPS in vivo in attempts to establish a model of premature parturition induced by the pro-inflammatory response. Uterine explants were incubated in vitro to determine the effects of IL-6 on uterine synthesis of oxytocin (OT) and its receptor (OTR). RESULTS: LPS injection was quite toxic to pregnant rats and gave extremely variable results. In animals that delivered, there was a marked increase in the uterine concentrations of OTR and OTR mRNA. There was no consistent effect regarding the timing of parturition. IL-6 caused a significant increase in the concentration of OTR mRNA in uterine explants from pregnant rats but not in tissues from non-pregnant animals. CONCLUSION: Rat uterine concentrations of OTR are regulated by IL-6. Pro-inflammatory cytokines may stimulate uterine contractility in late gestation rat uterine tissues through a mechanism involving stimulation of OTR.

引用

页码：65 / 72

页数：8

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