Role of lipid emulsions in cholestasis associated with long-term parenteral nutrition in children

被引:212
作者
Colomb, V [1 ]
Jobert-Giraud, A [1 ]
Lacaille, F [1 ]
Goulet, O [1 ]
Fournet, JC [1 ]
Ricour, C [1 ]
机构
[1] Hop Necker Enfants Malad, F-75743 Paris 15, France
关键词
D O I
10.1177/0148607100024006345
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: In children who depend on longterm parenteral nutrition (PN), liver disease is a major complication that may lead to end-stage liver failure requiring liver transplantation. Methods: This retrospective study investigated the influence of lipid emulsions on cholestasis onset in children receiving long-term total parenteral nutrition (TPN) with lipids. Ten children who presented with a total of 23 episodes of cholestasis, associated in 13 cases with thrombocytopenia, were studied. Results: Changes in the lipid delivery preceded these complications in more than half the cases. The temporary decrease in lipid administration led to normalization of bilirubin in 17 episodes. Conclusions: These data suggest that lipid supply is one of the risk factors for PN-associated cholestasis. The link between cholestasis and the reticuloendothelial system overload needs to he better understood. Prevention of cholestasis might include the decrease in the lipid load. When cholestasis occurs, lipid supply should be temporarily stopped, especially in the case of associated thrombocytopenia.
引用
收藏
页码:345 / 350
页数:6
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