A titanium-catalyzed three-component coupling to generate α,β-unsaturated β-iminoamines

被引:123
作者
Cao, CS [1 ]
Shi, YH [1 ]
Odom, AL [1 ]
机构
[1] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
关键词
D O I
10.1021/ja0284714
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The three-component coupling of an amine, alkyne, and isonitrile is facilitated by a titanium complex bearing the N,N-di(pyrrolyl-α-methyl)-N-methylamine (dpma) ligand. From this methodology, α,β-unsaturated β-iminoamines are generated regioselectively with many substrates and are available on multigram scales. Copyright © 2003 American Chemical Society.
引用
收藏
页码:2880 / 2881
页数:2
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