Comprehensive geriatric assessment of elderly highlanders in Qinghai, China, III: Oxidative stress and aging in Tibetan and Han elderly highlanders

被引：9

作者：

Sakamoto, Ryota ^{[1
]}

Matsubayashi, Kozo ^{[2
]}

Kimura, Yumi ^{[4
]}

Ishine, Masayuki

Kosaka, Yasuyuki

Wada, Taizo ^{[2
]}

Wada, Chizu

Nakatsuka, Masahiro ^{[4
]}

Ishimoto, Yasuko ^{[3
]}

Hirosaki, Mayumi ^{[3
]}

Kasahara, Yoriko ^{[3
]}

Konno, Akiko ^{[3
]}

Chen, Wingling ^{[3
]}

Fujisawa, Michiko ^{[5
]}

Otsuka, Kuniaki ^{[6
]}

Nakashima, Michiro

Wang, Hongxin ^{[7
]}

Dai, Qingxiang ^{[7
]}

Yang, Airong ^{[7
]}

Qiao, Haisheng

Gao, Jidong ^{[7
]}

Li, Zhanquan ^{[7
]}

Zhang, Yongshou

Ge, Ri-Li ^{[8
]}

Okumiya, Kiyohito

机构：

[1] Kyoto Univ, Sch Publ Hlth, Res Inst Humanity & Nat, Kita Ku, Kyoto 6038047, Japan

[2] Kyoto Univ, Sch Publ Hlth, Ctr SE Asian Studies, Kyoto 6038047, Japan

[3] Kyoto Univ, Sch Publ Hlth, Dept Field Med, Kyoto 6038047, Japan

[4] Kyoto Univ, Grad Sch Med, Human Brain Res Ctr, Kyoto 6038047, Japan

[5] Kyoto Univ, Wildlife Res Ctr, Kyoto 6038047, Japan

[6] Tokyo Womens Med Univ, Dept Med, Med Ctr E, Tokyo, Japan

[7] Qinghai Univ, Affiliated Hosp, Qinghai, Peoples R China

[8] Qinghai Univ, Res Ctr High Altitude Med, Qinghai, Peoples R China

来源：

GERIATRICS & GERONTOLOGY INTERNATIONAL | 2009年 / 9卷 / 04期

关键词：

aging; elderly highlanders; oxidative stress; reactive oxygen species; HIGH-ALTITUDE HYPOXIA; NITRIC-OXIDE; SELF-CARE; COMMUNITY; ADAPTATION; PEOPLE; ANTIOXIDANTS; IMPROVEMENT; JAPANESE; PATTERN;

D O I：

10.1111/j.1447-0594.2009.00544.x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Background: Although there are several factors which may contribute to oxidative stress at high altitude, little is known about the association between oxidative stress and aging in the community-dwelling elderly in the Tibetan Plateau. Methods: Reactive oxygen species (ROS) and comprehensive geriatric functions were examined among 235 community-dwelling elderly subjects aged 60 years or more (146 Hans and 89 Tibetans). As a marker of ROS, the levels of reactive oxygen metabolites (ROM) were measured using the d-ROM test. Results: The rate of dependence of basic activities of daily living (basic ADL) among Tibetan elderly highlanders was significantly higher than that among Han elderly highlanders. The d-ROM level was higher among the Tibetan elderly than those among the Han elderly (Tibetan 465.6 +/- 97.9 Carr U, Han 415.3 +/- 72.0 Carr U, P = 0.003). The ROM level was higher among women than those among men. Stepwise multiple regression analysis showed that being Tibetan, female, and oxygen saturation were independent predictors of increasing d-ROM level (Tibetan beta, 0.241; female beta, 0.206; oxygen saturation beta, 0.218). The high levels of ROM (d-ROM > 500 Carr U) were significantly associated with dependence of basic ADL after adjustment for age, sex and ethnicity (odds ratio = 2.51, P = 0.028). Conclusion: The findings of this study imply the possibility that ROS is higher among Tibetan elderly highlanders than that of Han, which related to the geriatric items. Further studies are needed to show the impact of oxidative stress on the aging of highlanders.

引用

页码：352 / 358

页数：7

共 42 条

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