Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris

被引：104

作者：

Kikuchi, Yoku

Ito, Kenta ^{[1
]}

Ito, Yoshitaka

Shiroto, Takashi

Tsuburaya, Ryuji

Aizawa, Kentaro

Hao, Kiyotaka

Fukumoto, Yoshihiro

Takahashi, Jun

Takeda, Morihiko

Nakayama, Masaharu

Yasuda, Satoshi

Kuriyama, Shinichi ^{[2
]}

Tsuji, Ichiro ^{[2
]}

Shimokawa, Hiroaki

机构：

[1] Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Aoba Ku, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Publ Hlth & Forens Med, Sendai, Miyagi 9808574, Japan

来源：

CIRCULATION JOURNAL | 2010年 / 74卷 / 03期

关键词：

Angina pectoris; Angiogenesis; Myocardial ischemia; Shock wave; RANDOMIZED CONTROLLED-TRIAL; MYOCARDIAL-ISCHEMIA; CELLS; DISEASE; HEART; PIGS;

D O I：

10.1253/circj.CJ-09-1028

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris. Methods and Results: To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects. Conciusions: Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris. (Circ J 2010; 74: 589-591)

引用

收藏

页码：589 / 591

页数：3

相关论文

共 15 条

[1] Low-energy shock wave for enhancing recruitment of endothelial progenitor cells - A new modality to increase efficacy of cell therapy in chronic hind limb ischemia [J].

Aicher, Alexandra ;

Heeschen, Christopher ;

Sasaki, Ken-ichiro ;

Urbich, Carmen ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION, 2006, 114 (25) :2823-2830

[2] Unchain my heart: the scientific foundations of cardiac repair [J].

Dimmeler, S ;

Zeiher, AM ;

Schneider, MD .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (03) :572-583

[3] Therapeutic interventions for enhancing collateral development by administration of growth factors: basic principles, early results and potential hazards [J].

Epstein, SE ;

Fuchs, S ;

Zhou, YF ;

Baffour, R ;

Kornowski, R .

CARDIOVASCULAR RESEARCH, 2001, 49 (03) :532-542

[4] Extracorporeal cardiac shock wave therapy ameliorates myocardial ischemia in patients with severe coronary artery disease [J].

Fukumoto, Y ;

Ito, A ;

Uwatoku, T ;

Matoba, T ;

Kishi, T ;

Tanaka, H ;

Takeshita, A ;

Sunagawa, K ;

Shimokawa, H .

CORONARY ARTERY DISEASE, 2006, 17 (01) :63-70

[5] Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy [J].

Gnecchi, Massimiliano ;

Zhang, Zhiping ;

Ni, Aiguo ;

Dzau, Victor J. .

CIRCULATION RESEARCH, 2008, 103 (11) :1204-1219

[6] Human Studies of Angiogenic Gene Therapy [J].

Gupta, Rajesh ;

Tongers, Joern ;

Losordo, Douglas W. .

CIRCULATION RESEARCH, 2009, 105 (08) :724-736

[7] Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy [J].

Ito, Kenta ;

Fukumoto, Yoshihiro ;

Shimokawa, Hiroaki .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 219 (01) :1-9

[8] Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina -: A phase I/IIa double-blind, randomized controlled trial [J].

Losordo, Douglas W. ;

Schatz, Richard A. ;

White, Christopher J. ;

Udelson, James E. ;

Veereshwarayya, Vimal ;

Durgin, Michelle ;

Poh, Kian Keong ;

Weinstein, Robert ;

Kearney, Marianne ;

Chaudhry, Muqtada ;

Burg, Aaron ;

Eaton, Liz ;

Heyd, Lindsay ;

Thorne, Tina ;

Shturman, Leon ;

Hoffmeister, Peter ;

Story, Ken ;

Zak, Victor ;

Dowling, Douglas ;

Traverse, Jay H. ;

Olson, Rachel E. ;

Flanagan, Janice ;

Sodano, Donata ;

Murayama, Toshinori ;

Kawamoto, Atsuhiko ;

Kusano, Kengo Fukushima ;

Wollins, Jill ;

Welt, Frederick ;

Shah, Pinak ;

Soukas, Peter ;

Asahara, Takayuki ;

Henry, Timothy D. .

CIRCULATION, 2007, 115 (25) :3165-3172

[9] Age-Period-Cohort analysis of mortality due to ischemic heart disease in Japan, 1955 to 2000 [J].

Ma, Enbo ;

Iso, Hiroyasu ;

Takahashi, Hideto ;

Yamagishi, Kazumasa ;

Tanigawa, Takeshi .

CIRCULATION JOURNAL, 2008, 72 (06) :966-972

[10] Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo [J].

Nishida, T ;

Shimokawa, H ;

Oi, K ;

Tatewaki, H ;

Uwatoku, T ;

Abe, K ;

Matsumoto, Y ;

Kajihara, N ;

Eto, M ;

Matsuda, T ;

Yasui, H ;

Takeshita, A ;

Sunagawa, K .

CIRCULATION, 2004, 110 (19) :3055-3061