The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice

被引：642

作者：

Guillou, Herve ^{[2
]}

Zadravec, Damir ^{[1
]}

Martin, Pascal G. P. ^{[2
]}

Jacobsson, Anders ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab F3, Wenner Gren Inst, Dept Physiol, SE-10691 Stockholm, Sweden

[2] INRA, UR66, Lab Pharmacol & Toxicol, F-31931 Toulouse, France

来源：

PROGRESS IN LIPID RESEARCH | 2010年 / 49卷 / 02期

关键词：

Elongase; Desaturase; VLCFA; PUFA; Knockout mice; STEAROYL-COA DESATURASE-1; COENZYME-A DESATURASE; BROWN ADIPOSE-TISSUE; PERMEABILITY BARRIER FUNCTION; ELEMENT-BINDING PROTEIN-1; ACTIVATED RECEPTOR-ALPHA; CHAIN ELONGATION SYSTEM; INDUCED GENE-EXPRESSION; CYTOCHROME B(5) DOMAIN; RAT-LIVER;

D O I：

10.1016/j.plipres.2009.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the past decade, a great deal has been learnt about these enzymes and the first part of this review summarizes our current knowledge concerning these enzymes. More recently, several transgenic mouse models lacking either an elongase (Elovl3(-/-), Elovl4(-/-), Elovl5(-/-), Elovl6(-/-)) or a desaturase (Scd-1(-/-), Scd-2(-/-), Fads2(-/-)) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：186 / 199

页数：14

共 172 条

[1] Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids [J].

Agbaga, Martin-Paul ;

Brush, Richard S. ;

Mandal, Md Nawajes A. ;

Henry, Kimberly ;

Elliott, Michael H. ;

Anderson, Robert E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (35) :12843-12848

[2] Molecular cloning and functional characterization of rat Δ-6 fatty acid desaturase [J].

Aki, T ;

Shimada, Y ;

Inagaki, K ;

Higashimoto, H ;

Kawamoto, S ;

Shigeta, S ;

Ono, K ;

Suzuki, O .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 255 (03) :575-579

[3] Elovl3:: a model gene to dissect homeostatic links between the circadian clock and nutritional status [J].

Anzulovich, Ana ;

Mir, Alain ;

Brewer, Michelle ;

Ferreyra, Gabriela ;

Vinson, Charles ;

Baler, Ruben .

JOURNAL OF LIPID RESEARCH, 2006, 47 (12) :2690-2700

[4] ALTERATION OF A YEAST SH3 PROTEIN LEADS TO CONDITIONAL VIABILITY WITH DEFECTS IN CYTOSKELETAL AND BUDDING PATTERNS [J].

BAUER, F ;

URDACI, M ;

AIGLE, M ;

CROUZET, M .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (08) :5070-5084

[5]

Bernstein PS, 2001, INVEST OPHTH VIS SCI, V42, P3331

[6] THE EFFECTS OF PARTIALLY HYDROGENATED MARINE OILS ON THE MITOCHONDRIAL-FUNCTION AND MEMBRANE PHOSPHOLIPID FATTY-ACIDS IN RAT-HEART [J].

BLOMSTRAND, R ;

SVENSSON, L .

LIPIDS, 1983, 18 (03) :151-170

[7] LIGNOCERIC ACID BIOSYNTHESIS IN DEVELOPING BRAIN - ACTIVITIES OF MITOCHONDRIAL ACETYL-COA-DEPENDENT SYNTHESIS AND MICROSOMAL MALONYL-COA CHAIN-ELONGATING SYSTEM IN RELATION TO MYELINATION - COMPARISON BETWEEN NORMAL MOUSE AND DYSMYELINATING MUTANTS (QUAKING AND JIMPY) [J].

BOURRE, JM ;

PATURNEAUJOUAS, MY ;

DAUDU, OL ;

BAUMANN, NA .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 72 (01) :41-47

[8]

BRENNER RR, 1966, J BIOL CHEM, V241, P5213

[9] Steroid hormones control circadian Elovl3 expression in mouse liver [J].

Brolinson, Annelie ;

Fourcade, Stephane ;

Jakobsson, Andreas ;

Pujol, Aurora ;

Jacobsson, Anders .

ENDOCRINOLOGY, 2008, 149 (06) :3158-3166

[10] Lipid rafts, detergent-resistant membranes, and raft targeting signals [J].

Brown, Deborah A. .

PHYSIOLOGY, 2006, 21 :430-439

← 1 2 3 4 5 6 7 8 9 10 →