The modulation of host cell apoptosis by intracellular bacterial pathogens

被引:202
作者
Gao, LY
Kwaik, YA
机构
[1] Univ Calif San Francisco, Program Microbial Pathogenesis & Host Def, San Francisco, CA 94143 USA
[2] Univ Kentucky, Dept Microbiol & Immunol, Chandler Med Ctr, Lexington, KY 40536 USA
关键词
D O I
10.1016/S0966-842X(00)01784-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent years have witnessed significant advances in unraveling the elegant mechanisms by which intracellular bacterial pathogens induce and/or block apoptosis, which can influence disease progression. This intriguing aspect of the host-pathogen interaction adds another fascinating dimension to our understanding of the exploitation of host cell biology by intracellular bacterial pathogens.
引用
收藏
页码:306 / 313
页数:8
相关论文
共 74 条
[11]   Expression of Legionella pneumophila virulence traits in response to growth conditions [J].
Byrne, B ;
Swanson, MS .
INFECTION AND IMMUNITY, 1998, 66 (07) :3029-3034
[12]   Salmonella spp are cytotoxic for cultured macrophages [J].
Chen, LM ;
Kaniga, K ;
Galan, JE .
MOLECULAR MICROBIOLOGY, 1996, 21 (05) :1101-1115
[13]   Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate [J].
Clemens, DL ;
Lee, BY ;
Horwitz, MA .
INFECTION AND IMMUNITY, 2000, 68 (05) :2671-2684
[14]   NF-κB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection [J].
Clifton, DR ;
Goss, RA ;
Sahni, SK ;
van Antwerp, D ;
Baggs, RB ;
Marder, VJ ;
Silverman, DJ ;
Sporn, LA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4646-4651
[15]   Cleavage of Rabaptin-5 blocks endosome fusion during apoptosis [J].
Cosulich, SC ;
Horiuchi, H ;
Zerial, M ;
Clarke, PR ;
Woodman, PG .
EMBO JOURNAL, 1997, 16 (20) :6182-6191
[16]  
Dellacasagrande J, 1999, J IMMUNOL, V162, P2259
[17]   A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [J].
Enari, M ;
Sakahira, H ;
Yokoyama, H ;
Okawa, K ;
Iwamatsu, A ;
Nagata, S .
NATURE, 1998, 391 (6662) :43-50
[18]   Addiction modules and programmed cell death and antideath in bacterial cultures [J].
Engelberg-Kulka, H ;
Glaser, G .
ANNUAL REVIEW OF MICROBIOLOGY, 1999, 53 :43-70
[19]   Inhibition of apoptosis in Chlamydia-infected cells: Blockade of mitochondrial cytochrome c release and caspase activation [J].
Fan, T ;
Lu, H ;
Hu, H ;
Shi, LF ;
McClarty, GA ;
Nance, DM ;
Greenberg, AH ;
Zhong, GM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (04) :487-496
[20]  
Fratazzi C, 1997, J IMMUNOL, V158, P4320