Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders

被引：19

作者：

Lebovitz, Yeonwoo ^{[1
]}

Ringel-Scaia, Veronica M. ^{[1
]}

Allen, Irving C. ^{[1
,2
,3
]}

Theus, Michelle H. ^{[1
,2
,3
,4
]}

机构：

[1] Virginia Tech, Grad Program Translat Biol Med & Hlth, Blacksburg, VA 24061 USA

[2] Virginia Maryland Coll Vet Med, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24060 USA

[3] Virginia Tech, Dept Basic Sci Educ, Carilion Sch Med, Roanoke, VA USA

[4] Virginia Maryland Coll Vet Med, Ctr Regenerat Med, Blacksburg, VA 24060 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷

基金：

美国国家卫生研究院;

关键词：

autism; bacterial metabolites; gut bacteria; lactobacillus; microbiota; neurodevelopment; neuroimmune; CHAIN FATTY-ACIDS; AUTISM SPECTRUM DISORDER; GUT MICROBIOTA; SODIUM-BUTYRATE; COMMENSAL BACTERIA; MATERNAL INFECTION; NERVOUS-SYSTEM; 1ST YEAR; BRAIN; ACTIVATION;

D O I：

10.3389/fimmu.2018.01993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

From immunology to neuroscience, interactions between the microbiome and host are increasingly appreciated as potent drivers of health and disease. Epidemiological studies previously identified compelling correlations between perinatal microbiome insults and neurobehavioral outcomes, the mechanistic details of which are just beginning to take shape thanks to germ-free and antibiotics-based animal models. This review summarizes parallel developments from clinical and preclinical research that suggest neuroactive roles for gut bacteria and their metabolites. We also examine the nascent field of microbiome-microglia crosstalk research, which includes pharmacological and genetic strategies to inform functional capabilities of microglia in response to microbial programming. Finally, we address an emerging hypothesis behind neurodevelopmental disorders, which implicates microbiome dysbiosis in the atypical programming of neuroimmune cells, namely microglia.

引用

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