A modular approach to DNA-programmed self-assembly of macromolecular nanostructures

被引：57

作者：

Gothelf, KV

Brown, RS

机构：

[1] Aarhus Univ, Dept Chem, DK-8000 Aarhus C, Denmark

[2] Harvard Univ, Div Expt Med, Beth Israel Deaconess Med Ctr, Inst Med, Boston, MA 02115 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2005年 / 11卷 / 04期

关键词：

DNA structures; nanostructures; oligonucleotides; self-assembly; template synthesis;

D O I：

10.1002/chem.200400646

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-programmed organic reactions are new and powerful tools for assembling chemical compounds into predetermined complex structures and a brief review of their use is given. This approach is particular efficient for the selection and covalent coupling of multiple components. DNA-templated synthesis is used for polymerization of PNA tetramers and for copying of the connectivity information in DNA. Direct DNA-programmed multicomponent coupling of custom designed organic modules is described. The macromolecular structures obtained are highly conjugated potentially conducting nanoscaffolds. Some future developments in this area are discussed.

引用

页码：1062 / 1069

页数：8

共 56 条

[31] The developments of semisynthetic DNA-protein conjugates [J].