Modified nucleosides from nitrones: a new and efficient stereoselective approach to isoxazolidinyl thymidine derivatives

被引：45

作者：

Merino, P ^{[1
]}

Franco, S ^{[1
]}

Garces, N ^{[1
]}

Merchan, FL ^{[1
]}

Tejero, T ^{[1
]}

机构：

[1] Univ Zaragoza, ICMA, Dept Quim Organ, E-50009 Zaragoza, Aragon, Spain

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 04期

关键词：

D O I：

10.1039/a705673g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The addition of the sodium enolate of methyl acetate to the N-benzyl nitrone 4 derived from D-glyceraldehyde affords the 3-substituted isoxazolidin-5-one 6a with a high degree of syn selectivity and in quantitative chemical yield; its further elaboration leads to the preparation of the important isoxazolidine nucleoside analogue 2a in enantiomerically pure form.

引用

页码：493 / 494

页数：2

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