An Overview of APP Processing Enzymes and Products

被引：520

作者：

Chow, Vivian W. ^{[2
]}

Mattson, Mark P. ^{[1
]}

Wong, Philip C. ^{[2
]}

Gleichmann, Marc ^{[1
]}

机构：

[1] NIA, Neurosci Lab, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Div Neuropathol, Baltimore, MD 21205 USA

来源：

NEUROMOLECULAR MEDICINE | 2010年 / 12卷 / 01期

关键词：

Amyloid beta; alpha-secretase; beta-secretase; gamma-secretase; APP; AICD; AMYLOID-PRECURSOR-PROTEIN; BETA-SECRETASE CLEAVAGE; CELLULAR PRION PROTEIN; ALZHEIMERS-DISEASE; GAMMA-SECRETASE; ALPHA-SECRETASE; A-BETA; CATHEPSIN-B; SYNAPTIC PLASTICITY; CEREBROSPINAL-FLUID;

D O I：

10.1007/s12017-009-8104-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The generation of amyloid beta-peptide (A beta) by enzymatic cleavages of the beta-amyloid precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While the basic process of beta- and gamma-secretase-mediated generation of Ab is text book knowledge, new aspects of Ab and other cleavage products have emerged in recent years. Also our understanding of the enzymes involved in APP proteolysis has increased dramatically. All of these discoveries contribute to a more complete understanding of APP processing and the physiologic and pathologic roles of its secreted and intracellular protein products. Understanding APP processing is important for any therapeutic strategy aimed at reducing Ab levels in AD. In this review, we provide a concise description of the current state of understanding the enzymes involved in APP processing, the cleavage products generated by different processing patterns, and the potential functions of those cleavage products.

引用

页码：1 / 12

页数：12

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