Complete sequence of the G glycoprotein gene of avian metapneumovirus subgroup C and identification of a divergent domain in the predicted protein

被引：28

作者：

Govindarajan, D ^{[1
]}

Yunus, AS ^{[1
]}

Samal, SK ^{[1
]}

机构：

[1] Univ Maryland, Virginia Maryland Reg Coll Vet Med, College Pk, MD 20742 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2004年 / 85卷

关键词：

D O I：

10.1099/vir.0.80400-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The complete nucleotide sequences of the attachment glycoprotein (G) genes of three strains of avian metapneumovirus subgroup C (AMPV-C) were determined from the viral genomic and mRNAs. The G gene of AMPV-C was 1798 nt (1015 nt longer than previously reported) and the derived polypeptide had 585 aa. The deduced amino acid sequence of the predicted G protein of AMPV-C strain Colorado (AMPV-CO) showed 21-25 % amino acid identity to the G proteins of human metapneumoviruses, but only 14-16 % amino acid identity to those of other AMPV subgroups. The predicted G protein of AMPV-CO showed 98 and 81 % amino acid identity to those of AMPV-C strains Mn-1a and Mn-2a, respectively, indicating considerable sequence variation in the G proteins of AMPV-C isolates. Comparison of the G protein sequences of AMPV-CO and Mn-2a identified a highly divergent domain (48% amino acid identity) at as 300-450.

引用

页码：3671 / 3675

页数：5

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