Complete sequence of the G glycoprotein gene of avian metapneumovirus subgroup C and identification of a divergent domain in the predicted protein

被引：28

作者：

Govindarajan, D ^{[1
]}

Yunus, AS ^{[1
]}

Samal, SK ^{[1
]}

机构：

[1] Univ Maryland, Virginia Maryland Reg Coll Vet Med, College Pk, MD 20742 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 2004年 / 85卷

关键词：

D O I：

10.1099/vir.0.80400-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The complete nucleotide sequences of the attachment glycoprotein (G) genes of three strains of avian metapneumovirus subgroup C (AMPV-C) were determined from the viral genomic and mRNAs. The G gene of AMPV-C was 1798 nt (1015 nt longer than previously reported) and the derived polypeptide had 585 aa. The deduced amino acid sequence of the predicted G protein of AMPV-C strain Colorado (AMPV-CO) showed 21-25 % amino acid identity to the G proteins of human metapneumoviruses, but only 14-16 % amino acid identity to those of other AMPV subgroups. The predicted G protein of AMPV-CO showed 98 and 81 % amino acid identity to those of AMPV-C strains Mn-1a and Mn-2a, respectively, indicating considerable sequence variation in the G proteins of AMPV-C isolates. Comparison of the G protein sequences of AMPV-CO and Mn-2a identified a highly divergent domain (48% amino acid identity) at as 300-450.

引用

页码：3671 / 3675

页数：5

共 27 条

[21]

TOQUIN D, 1992, P SEM NEW EV VIR DIS, P111

[22] Analysis of the genomic sequence of a human metapneumovirus [J].

van den Hoogen, BG ;

Bestebroer, TM ;

Osterhaus, ADME ;

Fouchier, RAM .

VIROLOGY, 2002, 295 (01) :119-132

[23] A newly discovered human pneumovirus isolated from young children with respiratory tract disease [J].

van den Hoogen, BG ;

de Jong, J ;

Groen, J ;

Kuiken, T ;

de Groot, R ;

Fouchier, RAM ;

Osterhaus, ADME .

NATURE MEDICINE, 2001, 7 (06) :719-724

[24] CILIOSTATIC AGENT FOUND IN RHINOTRACHEITIS [J].

WILDING, GP ;

BAXTERJONES, C ;

GRANT, M .

VETERINARY RECORD, 1986, 118 (26) :735-735

[25] ANTIBODIES TO TRT IN CHICKENS WITH SWOLLEN HEAD SYNDROME [J].

WYETH, PJ ;

CHETTLE, NJ ;

GOUGH, RE ;

COLLINS, MS .

VETERINARY RECORD, 1987, 120 (12) :286-287

[26] CLONING AND SEQUENCING OF THE MATRIX PROTEIN (M) GENE OF TURKEY RHINOTRACHEITIS VIRUS REVEAL A GENE ORDER DIFFERENT FROM THAT OF RESPIRATORY SYNCYTIAL VIRUS [J].

YU, Q ;

DAVIS, PJ ;

LI, J ;

CAVANAGH, D .

VIROLOGY, 1992, 186 (02) :426-434

[27] Deduced amino acid sequence of the small hydrophobic protein of US avian pneumovirus has greater identity with that of human metapneumovirus than those of non-US avian pneumoviruses [J].

Yunus, AS ;

Govindarajan, D ;

Huang, ZH ;

Samal, SK .

VIRUS RESEARCH, 2003, 93 (01) :91-97

← 1 2 3 →