Adaptive immunity and atherosclerosis

被引：218

作者：

Andersson, John ^{[1
]}

Libby, Peter ^{[2
,3
,4
]}

Hansson, Goran K. ^{[1
,2
,3
]}

机构：

[1] Karolinska Univ Hosp, Ctr Mol Med, Dept Med, Karolinska Inst, SE-17176 Stockholm, Sweden

[2] Brigham & Womens Hosp, Leducq Transatlantic Network Excellence Cardiovas, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Donald W Reynolds Cardiovasc Clin Res Ctr, Boston, MA 02115 USA

来源：

CLINICAL IMMUNOLOGY | 2010年 / 134卷 / 01期

关键词：

Atherosclerosis; T cells; Th1; Th2; Regulatory T cells; Costimulation; Coinhibition; Pro-inflammatory cytokines; Anti-inflammatory cytokines; Statins; SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; COA REDUCTASE INHIBITORS; RECEPTOR-DEFICIENT MICE; REGULATORY T-CELLS; CHOLESTEROL-INDUCED ATHEROSCLEROSIS; CXC CHEMOKINE RECEPTOR-5; INTERFERON-GAMMA; IFN-GAMMA; REDUCES ATHEROSCLEROSIS;

D O I：

10.1016/j.clim.2009.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis involves the formation of inflammatory arterial lesions and is one of the most common causes of death globally. It has been evident for more than 20 years that adaptive immunity and T cells in particular regulate the magnitude of the atherogenic pro-inflammatory response. T cells also influence the stability of the atherosclerotic lesion and thus the propensity for thrombus formation and the clinical outcome of disease. This review summarizes our current understanding of T cells in atherogenesis, including which antigens they recognize, the rote of T cell costimulation/coinhibition, and their secretion of pro- and anti-inflammatory mediators. Furthermore, we outline future areas of research and potential clinical intervention strategies. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：33 / 46

页数：14

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