LVV-hemorphin-7 lowers blood pressure in spontaneously hypertensive rats:: Radiotelemetry study

被引：21

作者：

Cejka, J

Zelezná, B

Velek, J

Zicha, J

Kuntes, J ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague, Czech Republic

[2] Acad Sci Czech Republ, Ctr Expt Res Cardiovasc Dis, CR-14220 Prague, Czech Republic

[3] Acad Sci Czech Republ, Inst Mol Genet, CR-14220 Prague, Czech Republic

[4] Acad Sci Czech Republ, Inst Organ Res Cardiovasc Dis, CR-14220 Prague, Czech Republic

[5] Acad Sci Czech Republ, Inst Organ Chem & Biochem, CR-14220 Prague, Czech Republic

来源：

PHYSIOLOGICAL RESEARCH | 2004年 / 53卷 / 06期

关键词：

hemorphin; blood pressure; heart rate; hypertension; rat;

D O I：

10.33549/physiolres.930728

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

Cardiovascular effects of LVV-hemorphin-7, a member of the family of fragments from beta-chain of human or bovine hemoglobin, were studied in conscious spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats by radiotelemetry. Intraperitoneal injection of hemorphin in a dose of 100 mug/kg significantly decreased blood pressure in SHR, whereas negligible effect was seen in normotensive WKY rats. Blood pressure changes were accompanied by reduction of heart rate. In conclusion, a direct effect of LVV-hemorphin-7 on blood pressure was demonstrated in SHR. These biologically active peptides could be involved in blood pressure regulation especially in hypertensive rats. but the precise mechanism should be elucidated.

引用

页码：603 / 607

页数：5

共 25 条

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Evidence that the angiotensin IV (AT4) receptor is the enzyme insulin-regulated aminopeptidase [J].