PD-1 Shapes B Cells as Evildoers in the Tumor Microenvironment

被引：37

作者：

Ren, Zhenhua ^{[1
,2
]}

Peng, Hua ^{[1
]}

Fu, Yang-Xin ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Key Lab Infect & Immun, Beijing 100080, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Univ Texas SW Med Ctr Dallas, Dept Pathol, 6000 Harry Hines Blvd, Dallas, TX 75235 USA

来源：

CANCER DISCOVERY | 2016年 / 6卷 / 05期

关键词：

INDUCTION;

D O I：

10.1158/2159-8290.CD-16-0307

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Protumorigenic PD-1(hi) B cells, induced in hepatocellular carcinoma, suppress tumor-specific T-cell response via IL10-dependent pathways upon PD-1/PD-L1 interaction. Anti-PD-1 or anti-PD-L1 antibodies may function not only through blocking the PD-1 coinhibitory pathway in T cells but also via abolishing the suppressive function of regulatory B cells. (C) 2016 AACR.

引用

页码：477 / 478

页数：2

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