Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population

被引：108

作者：

Hotta, Kikuko ^{[1
]}

Nakamura, Michihiro

Nakamura, Takahiro ^{[2
,3
]}

Matsuo, Tomoaki ^{[4
]}

Nakata, Yoshio ^{[4
]}

Kamohara, Seika ^{[5
]}

Miyatake, Nobuyuki ^{[6
]}

Kotani, Kazuaki ^{[7
]}

Komatsu, Ryoya ^{[8
]}

Itoh, Naoto ^{[9
]}

Mineo, Ikuo ^{[10
]}

Wada, Jun ^{[11
]}

Masuzaki, Hiroaki ^{[12
]}

Yoneda, Masato ^{[13
]}

Nakajima, Atsushi ^{[13
]}

Funahashi, Tohru ^{[7
]}

Miyazaki, Shigeru ^{[14
]}

Tokunaga, Katsuto ^{[15
]}

Kawamoto, Manabu ^{[16
]}

Ueno, Takato ^{[17
]}

Hamaguchi, Kazuyuki ^{[18
]}

Tanaka, Kiyoji ^{[4
]}

Yamada, Kentaro ^{[19
]}

Hanafusa, Toshiaki ^{[20
]}

Oikawa, Shinichi ^{[21
]}

Yoshimatsu, Hironobu ^{[22
]}

Nakao, Kazuwa ^{[12
]}

Sakata, Toshiie ^{[22
]}

Matsuzawa, Yuji ^{[7
]}

Kamatani, Naoyuki ^{[2
]}

Nakamura, Yusuke ^{[23
]}

机构：

[1] RIKEN, Ctr Genom Med, Lab Endocrinol & Metab, Tsurumi Ku, Kanagawa 2300045, Japan

[2] RIKEN, Ctr Genom Med, Lab Stat Anal, Tokyo, Japan

[3] Natl Def Med Coll, Math Lab, Tokorozawa, Saitama 359, Japan

[4] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki, Japan

[5] Hlth Sci Univ, Yamanashi, Japan

[6] Okayama So Inst Hlth, Okayama, Japan

[7] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan

[8] Rinku Gen Med Ctr, Osaka, Japan

[9] Toyonaka City Hosp, Osaka, Japan

[10] Otemae Hosp, Osaka, Japan

[11] Okayama Univ, Grad Sch Med & Dent, Dept Med & Clin Sci, Okayama 7008530, Japan

[12] Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Kyoto, Japan

[13] Yokohama City Univ, Grad Sch Med, Div Gastroenterol, Yokohama, Kanagawa 232, Japan

[14] Tokyo Postal Serv Agcy Hosp, Tokyo, Japan

[15] Itami City Hosp, Itami, Hyogo, Japan

[16] Tokyo Womens Med Univ, Inst Rheumatol, Tokyo, Japan

[17] Kurume Univ, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 830, Japan

[18] Oita Univ, Fac Med, Dept Community Hlth & Gerontol Nursing, Oita 87011, Japan

[19] Kurume Univ, Dept Med, Div Endocrinol & Metab, Kurume, Fukuoka 830, Japan

[20] Osaka Med Coll, Dept Internal Med 1, Osaka, Japan

[21] Nippon Med Sch, Dept Med, Div Endocrinol & Metab, Tokyo 113, Japan

[22] Oita Univ, Fac Med, Dept Internal Med 1, Oita 87011, Japan

[23] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Mol Med Lab, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2009年 / 54卷 / 12期

关键词：

BDNF gene; FAIM2; gene; GNPDA2; Japanese; MC4R gene; obesity; SCE16B gene; TMEM18; GENOME-WIDE ASSOCIATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; SECRETORY GRANULES; SECRETOGRANIN-III; ADULT OBESITY; BODY-WEIGHT; EARLY-ONSET; RISK LOCI; FTO GENE; FAT MASS;

D O I：

10.1038/jhg.2009.106

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

There is evidence that the obesity phenotype in the Caucasian populations is associated with variations in several genes, including neuronal growth regulator 1 (NEGR1), SEC16 homolog B (SCE16B), transmembrane protein 18 (TMEM18), ets variant 5 (ETV5), glucosamine-6-phosphate deaminase 2 (GNPDA2), prolactin (PRL), brain-derived neurotrophic factor (BDNF), mitochondrial carrier homolog 2 (MTCH2), Fas apoptotic inhibitory molecule 2 (FAIM2), SH2B adaptor protein 1 (SH2B1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog (MAF), Niemann-Pick disease, type C1 (NPC1), melanocortin 4 receptor (MC4R) and potassium channel tetramerisation domain containing 15 (KCTD15). To investigate the relationship between obesity and these genes in the Japanese population, we genotyped 27 single-nucleotide polymorphisms (SNPs) in 14 genes from obese subjects (n=1129, body mass index (BMI) >= 30 kg m(-2)) and normal-weight control subjects (n=1736, BMI <25 kg m(-2)). The SNP rs10913469 in SEC16B (P=0.000012) and four SNPs (rs2867125, rs6548238, rs4854344 and rs7561317) in the TMEM18 gene (P=0.00015), all of which were in almost absolute linkage disequilibrium, were significantly associated with obesity in the Japanese population. SNPs in GNPDA2, BDNF, FAIM2 and MC4R genes were marginally associated with obesity (P<0.05). Our data suggest that some SNPs identified by genome-wide association studies in the Caucasians also confer susceptibility to obesity in Japanese subjects. Journal of Human Genetics (2009) 54, 727-731; doi: 10.1038/jhg.2009.106; published online 23 October 2009

引用

页码：727 / 731

页数：5

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