Molecular dissection of craniofacial development using zebrafish

被引:109
作者
Yelick, PC
Schilling, TF
机构
[1] Forsyth Inst, Dept Cytokine Biol, Boston, MA 02115 USA
[2] Harvard Forsyth Dept Oral Biol, Boston, MA 02115 USA
[3] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
关键词
molecular genetics; craniofacial development; zebrafish; ENU mutagenesis;
D O I
10.1177/154411130201300402
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The zebrafish, Danio rerio, is a small, freshwater teleost that only began to be used as a vertebrate genetic model by the late George Streisinger in the early 1980s. The strengths of the zebrafish complement genetic studies in mice and embryo-logical studies in avians. Its advantages include high fecundity, externally fertilized eggs and transparent embryos that can be easily manipulated, inexpensive maintenance, and the fact that large-scale mutagenesis screens can be performed. Here we review studies that have used the zebrafish as a model for craniofacial development. Lineage studies in zebrafish have defined the origins of the cranial skeleton at the single-cell level and followed the morphogenetic behaviors of these cells in skeletal condensations. Furthermore, genes identified by random mutational screening have now revealed genetic pathways controlling patterning of the jaw and other pharyngeal arches, as well as the midline of the skull, that are conserved between fish and humans. We discuss the potential impact of specialized mutagenesis screens and the future applications of this versatile, vertebrate developmental model system in the molecular dissection of craniofacial development.
引用
收藏
页码:308 / 322
页数:15
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