The effect of aldosterone on glucose metabolism

被引:92
作者
Corry, DB [1 ]
Tuck, ML [1 ]
机构
[1] Olive View UCLA Med Ctr, 14445 Olive View Dr, Sylmar, CA 91342 USA
关键词
D O I
10.1007/s11906-003-0065-2
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
There is an association of glucose intolerance and diabetes with primary aldosteronism, but the frequency and mechanisms are not clear. This paper reviews the possible mechanisms of impaired glucose metabolism in primary aldosteronism. Patients with primary aldosteronism can have impaired pancreatic insulin release and reduction in insulin sensitivity. These effects may be due to hypokalemia, but the evidence suggests other factors such as a direct impact of excess aldosterone on insulin action in contributing to the metabolic dysfunction. In general adrenal surgery in cases of aldosterone-producing adenoma will correct the metabolic abnormalities, but it is less sure if treatment with spironolactone in cases of idiopathic hyperplasia will correct impaired glucose tolerance.
引用
收藏
页码:106 / 109
页数:4
相关论文
共 30 条
  • [11] Serum leptin levels in patients with primary hyperaldosteronism before and after treatment:: relationships to insulin sensitivity
    Haluzík, M
    Sindelka, G
    Widimsky, J
    Prázny, M
    Zelinka, T
    Skrha, J
    [J]. JOURNAL OF HUMAN HYPERTENSION, 2002, 16 (01) : 41 - 45
  • [12] CORRECTABLE SUBSETS OF PRIMARY ALDOSTERONISM - PRIMARY ADRENAL-HYPERPLASIA AND RENIN RESPONSIVE ADENOMA
    IRONY, I
    KATER, CE
    BIGLIERI, EG
    SHACKLETON, CHL
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1990, 3 (07) : 576 - 582
  • [13] INCREASED INSULIN SENSITIVITY IN PATIENTS WITH ALDOSTERONE-PRODUCING ADENOMA
    ISHIMORI, M
    TAKEDA, N
    OKUMURA, S
    MURAI, T
    INOUYE, H
    YASUDA, K
    [J]. CLINICAL ENDOCRINOLOGY, 1994, 41 (04) : 433 - 438
  • [14] Aldosterone suppresses expression of an avian colonic sodium-glucose cotransporter
    Laverty, G
    Bjarnadóttir, S
    Elbrond, VS
    Arnason, SS
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 281 (04) : R1041 - R1050
  • [15] Mani H, 1999, Nihon Jinzo Gakkai Shi, V41, P442
  • [16] DIABETES AND ADRENAL DISEASE
    NESTLER, JE
    MCCLANAHAN, MA
    [J]. BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1992, 6 (04): : 829 - 847
  • [17] INVITRO EFFECTS OF INSULIN ON ALDOSTERONE PRODUCTION IN RAT ZONA GLOMERULOSA CELLS
    PETRASEK, D
    JENSEN, G
    TUCK, M
    STERN, N
    [J]. LIFE SCIENCES, 1992, 50 (23) : 1781 - 1787
  • [18] Genetic variation in aldosterone synthase predicts plasma glucose levels
    Ranade, K
    Wu, KD
    Risch, N
    Olivier, M
    Pei, D
    Hsiao, CF
    Chuang, LM
    Ho, LT
    Jorgenson, E
    Pesich, R
    Chen, YDI
    Dzau, V
    Lin, A
    Olshen, RA
    Curb, D
    Cox, DR
    Botstein, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (23) : 13219 - 13224
  • [19] EFFECT OF EXPERIMENTAL POTASSIUM-DEFICIENCY ON GLUCOSE AND INSULIN METABOLISM
    ROWE, JW
    TOBIN, JD
    ROSA, RM
    ANDRES, R
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 1980, 29 (06): : 498 - 502
  • [20] SAGILD U, 1961, ACTA MED SCAND, V169, P243