Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo

被引：22

作者：

Banerjee, Debasish

Hegedus, Balazs

Gutmann, David H.

Garbow, Joel R.

机构：

[1] Washington Univ, Sch Med, Dept Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA

来源：

NEUROIMAGE | 2007年 / 35卷 / 04期

关键词：

D O I：

10.1016/j.neuroimage.2007.02.019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One of the major limitations to preclinical mouse therapeutic evaluation is the inherent difficulty in imaging small tumors in vivo. We present a rapid and reliable method to detect optic glioma (OPG) in a mouse neurofibromatosis-1 model (Nf1(flox/mut)GFAP-Cre mice) in vivo using Manganese-Enhanced Magnetic Resonance Imaging (MEMRI). In a blinded study, 23 mice were chosen randomly from a cohort of Nf1(flox/mut)GFAP-Cre mice and two sets of age-matched controls. In all cases, OPG presence or absence was correctly identified. In addition, the OPG size and shape were accurately measured in vivo, facilitating the use of this model for preclinical drug studies. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1434 / 1437

页数：4

共 15 条

[1]

[Anonymous], J CHILD NEUROL

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