Imprint of human cytomegalovirus infection on the NK ceH receptor repertoire

被引:685
作者
Gumá, M
Angulo, A
Vilches, C
Gómez-Lozano, N
Malats, N
López-Botet, M
机构
[1] Univ Pompeu Fabra, Mol Immunopathol Unit, DCEXS, Barcelona 08003, Spain
[2] IDIBAPS, Barcelona, Spain
[3] Univ Madrid, Hosp Puerta Hierro, Serv Inmunol, Madrid 3, Spain
[4] IMM, E-08003 Barcelona, Spain
关键词
D O I
10.1182/blood-2004-05-2058
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Expression of the activating CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E was analyzed in peripheral blood lymphocytes (PBLs) from healthy adult blood donors; the expression of other natural killer (NK) cell receptors (ie, CD94/NKG2A, KIR, CD85j, CD161, NKp46, NKp30, and NKG2D) was also studied. Human cytomegalovirus (HCMV) infection as well as the HLA-E and killer immunoglobulin-like receptor (KIR) genotypes were considered as potentially relevant variables associated with CD94/NKG2C expression. The proportion of NKG2C(+) lymphocytes varied within a wide range ( < 0.1% to 22.1%), and a significant correlation (r = 0.83; P < .001) between NKG2C+ NK and T cells was noticed. The HLA-E genotype and the number of activating KIR genes of the donors were not significantly related to the percentage of NKG2C+ lymphocytes. By contrast, a positive serology for HCMV, but not for other herpesviruses (ie, Epstein-Barr and herpes simplex), turned out to be strongly associated (P < .001) with increased proportions of NKG2C+ NK and T cells. Remarkably, the CD94/NKG2C(+) population expressed lower levels of natural cytotoxicity receptors (NCRs) (ie, NKp30, NKp46) and included higher proportions of KIR+ and CD85j(+) cells than CD94/NKG2A(+) cells. Altogether, these data support that HCMV Infection selectively shapes the natural killer cell receptor (NKR) repertoire of NK and T cells from healthy carrier Individuals. (C) 2004 by The American Society of Hematology.
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页码:3664 / 3671
页数:8
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