Localization and regulation of cytosolic phospholipase A2

被引：153

作者：

Hirabayashi, T

Shimizu, T

机构：

[1] Univ Tokyo, Fac Med, Dept Biochem & Mol Biol, Bunkyo Ku, Tokyo 1130033, Japan

[2] CREST, Japan Sci & Technol Corp, Tokyo, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2000年 / 1488卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

Ca2+; C2; domain; phosphorylation; isoprenylation; phosphatidylinositol 4,5-bisphosphate; vimentin;

D O I：

10.1016/S1388-1981(00)00115-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Liberation of arachidonic acid by cytosolic phospholipase A(2) (cPLA(2)) upon cell activation is often the initial and rate-limiting step in leukotriene and prostaglandin biosynthesis. This review discusses the essential features of cPLA(2) isoforms and addresses intriguing insights into the catalytic and regulatory mechanisms. Gene expression, posttranslational modification and subcellular localization can regulate these isoforms. Translocation of cPLA(2)alpha from the cytosol to the perinuclear region in response to calcium transients is critical for the immediate arachidonic acid release. Therefore, particular emphasis is placed on the mechanism of the translocation and the role of the proteins and lipids implicated in this process. The regional distribution and cellular localization of cPLA(2) may help to better understand its function as an arachidonic acid supplier to downstream enzymes and as a regulator of specific cellular processes. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：124 / 138

页数：15

共 150 条

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