Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; results from the European prospective investigation into cancer and nutrition

被引：76

作者：

Cust, Anne E.

Allen, Naomi E.

Rinaldi, Sabina

Dossus, Laure

Friedenreich, Christine

Olsen, Anja

Tjonneland, Anne

Overvad, Kim

Clavel-Chapelon, Francoise

Boutron-Ruault, Marie-Christine

Linseisen, Jakob

Chang-Claude, Jenny

Boeing, Heiner

Schulz, Mandy

Benetou, Vassiliki

Trichopoulou, Antonia

Trichopoulos, Dimitrios

Palli, Domenico

Berrino, Franco

Tumino, Rosario

Mattiello, Amalia

Vineis, Paolo

Quiros, J. Ramon

Agudo, Antonio

Sanchez, Maria-Jose

Larranaga, Nerea

Navarro, Carmen

Ardanaz, Eva

Bueno-de-Mesquita, H. Bas

Peeters, Petra H. M.

van Gils, Carla H.

Bingham, Sheila

Khaw, Kay-Tee

Key, Tim

Slimani, Nadia

Riboli, Elio

Kaaks, Rudolf ^{[1
]}

机构：

[1] German Natl Canc Ctr, Div Canc Epidemiol, D-69120 Heidelberg, Germany

[2] Int Agcy Res Canc, Nutr & Hormones Unit, F-69372 Lyon, France

[3] Univ Sydney, Sch Publ Hlth, Sydney, NSW 2006, Australia

[4] Univ Lyon 1, Ctr Res Human Nutr Rhone Alpes, F-69365 Lyon, France

[5] Univ Oxford, Canc Res UK Epidemiol Unit, Oxford, England

[6] Alberta Canc Board, Div Populat Hlth & Informat, Calgary, AB, Canada

[7] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[8] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark

[9] Univ Paris Sud, INSERM, ER120, EA4045, Villejuif, France

[10] Inst Gustave Roussy, Villejuif, France

[11] German Inst Human Nutr Potsdam Rehbrucke, Dept Hyg & Epidemiol, Nuthetal, Germany

[12] Univ Athens, Sch Med, GR-11527 Athens, Greece

[13] CSPO Sci Inst Tuscany, Mol & Nutr Epidemiol Unit, Florence, Italy

[14] Natl Canc Inst, Epidemiol Unit, Milan, Italy

[15] Azienda Osped Civile MP Arezzo, Canc Registry, Ragusa, Italy

[16] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy

[17] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England

[18] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[19] Catalan Inst Oncol, IDIBELL, Dept Epidemiol, Barcelona, Spain

[20] Andalusian Sch Publ Hlth, Granada, Spain

[21] Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain

[22] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[23] Publ Hlth Inst Navarra, Pamplona, Spain

[24] Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, NL-3720 BA Bilthoven, Netherlands

[25] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[26] MRC Dunn Human Nutr Unit, Cambridge, England

[27] Univ Cambridge, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

INTERNATIONAL JOURNAL OF CANCER | 2007年 / 120卷 / 12期

基金：

英国医学研究理事会;

关键词：

endometrial cancer; insulin; IGFBP-1; IGFBP-2; C-peptide; prospective;

D O I：

10.1002/ijc.22578

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition, to examine the associations between prediagnostic serum concentrations of C-peptide, insulin-like growth factor binding protein (IGFBP)-l and IGFBP-2, and endometrial cancer risk. Among pre- and postmenopausal women, who were not currently using exogenous hormones, 286 women developed incident endometrial cancer during an average 5.1 years follow-up. Using risk set sampling, 555 matched control subjects were selected. In conditional logistic regression models adjusted for matching factors only, endometrial cancer risk increased with increasing serum levels of C-peptide (relative risks (RR) for the top vs. bottom quartile = 2.13 [95% confidence interval (CI) 1.33-3.41], p(trend) = 0.001, and decreasing serum levels of IGFBP-2 (RR for the lop vs. bottom quartile = 0.56 [95% CI 0.35-0.90], p(trend) = 0.03, but was not significantly associated with IGFBP-1 levels (RR for the top vs. bottom quartile = 0.76 [95% CI 0.47-1.21], p(trend) = 0.25). In BMI-adjusted models, only the C-peptide association remained marginally statistically significant (RR for the top vs. bottom quartile = 1.56 [95% CI 0.94-2.571, p(trend) = 0.05 for C-peptide; 0.84 [95% CI 0.50-1.40], p(trend) = 0.74 for IGFBP-2; and 1.08 [95% CI 0.65-1.781, p(trend) = 0.86 for IGFBP-1 levels). These associations were stronger among nonfasting women (<= 6 hr since last meal; 63% of subjects) but were not evident among fasting women, although the interactions were not statistically significant. The C-peptide-risk association was substantially attenuated after adjustment for free estradiol in postmenopausal women (RR for the top vs. bottom quartile = 1.28 [95 % CI 0.67-2.45], p(trend) = 0.42. Our results provide modest support to the hypothesis that hyperinsulinaemia is a risk factor for endometrial cancer. (c) 2007 Wiley-Liss, Inc.

引用

页码：2656 / 2664

页数：9

共 55 条

[31] Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone [J].