Towards the reconstruction of the bilaterian ancestral pre-MHC region

被引：26

作者：

Danchin, EGJ ^{[1
]}

Pontarotti, P ^{[1
]}

机构：

[1] Univ Aix Marseille 1, Equipe Phylogenom, EA 3781 Evolut Genome & Environm, F-13331 Marseille, 3, France

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 12期

关键词：

D O I：

10.1016/j.tig.2004.09.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this article, we describe how we reconstructed a precise, minimal proto-MHC region in the ancestor of euchordates, which was based on a comparison of the MHC-paralogy group of vertebrate with the MHC-like chromosome of cephalochordates. This deduced ancestral region was compared with the genomes of extant species, other deuterostomes and protostomes. Our analysis revealed statistically significant traces of conservation in these species, suggesting that a proto-MHC region existed at the origin of all bilaterian species. We also propose a new approach to reconstruct ancestral genomes, which combines both stringent statistical testing and phylogenetic analysis.

引用

页码：587 / 591

页数：5

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