An antecedent of the MHC-linked genomic region in amphioxus

被引:36
作者
Castro, LFC
Furlong, RF
Holland, PWH
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] UCL, Dept Biol, London WC1E 6BT, England
基金
英国生物技术与生命科学研究理事会;
关键词
genome evolution; paralogy; FISH;
D O I
10.1007/s00251-004-0642-9
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The MHC genes on human chromosome 6 are located within one of the best-characterised paralogy regions of the human genome. Numerous genes mapping around this location, 6p21, have paralogues at one, two or three other chromosomal locations on HSA 1, 9 and 19. The similarity between these four chromosomal regions suggests the linkages may have adaptive significance, and/or they may be echoes of segmental or genome duplication in human ancestry. Here, we show that six amphioxus cosmids, containing genes orthologous to those from the human MHC-linked paralogy regions, map to a single amphioxus chromosome. The composition of the MHC-linked genomic region, therefore, pre-dates vertebrate origins.
引用
收藏
页码:782 / 784
页数:3
相关论文
共 12 条
[1]   Evidence of en bloc duplication in vertebrate genomes [J].
Abi-Rached, L ;
Gilles, A ;
Shiina, T ;
Pontarotti, P ;
Inoko, H .
NATURE GENETICS, 2002, 31 (01) :100-105
[2]   Fluorescent in situ hybridisation to amphioxus chromosomes [J].
Castro, LFC ;
Holland, PWH .
ZOOLOGICAL SCIENCE, 2002, 19 (12) :1349-1353
[3]   Conservation of the MHC-like region throughout evolution [J].
Danchin, EGJ ;
Abi-Rached, L ;
Gilles, A ;
Pontarotti, P .
IMMUNOGENETICS, 2003, 55 (03) :141-148
[4]   Comparative genomics of the MHC: Glimpses into the evolution of the adaptive immune system [J].
Flajnik, MF ;
Kasahara, M .
IMMUNITY, 2001, 15 (03) :351-362
[5]   Were vertebrates octoploid? [J].
Furlong, RF ;
Holland, PWH .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2002, 357 (1420) :531-544
[6]   Phylogenetic tests of the hypothesis of block duplication of homologous genes on human chromosomes 6, 9, and 1 [J].
Hughes, AL .
MOLECULAR BIOLOGY AND EVOLUTION, 1998, 15 (07) :854-870
[7]   The chromosomal duplication model of the major histocompatibility complex [J].
Kasahara, M .
IMMUNOLOGICAL REVIEWS, 1999, 167 :17-32
[8]   The human Hox-bearing chromosome regions did arise by block or chromosome (or even genome) duplications [J].
Larhammar, D ;
Lundin, LG ;
Hallböök, F .
GENOME RESEARCH, 2002, 12 (12) :1910-1920
[9]   EVOLUTION OF THE VERTEBRATE GENOME AS REFLECTED IN PARALOGOUS CHROMOSOMAL REGIONS IN MAN AND THE HOUSE MOUSE [J].
LUNDIN, LG .
GENOMICS, 1993, 16 (01) :1-19
[10]   Evidence for 14 homeobox gene clusters in human genome ancestry [J].
Pollard, SL ;
Holland, PWH .
CURRENT BIOLOGY, 2000, 10 (17) :1059-1062