Titanium(IV) chloride and the amine-promoted Baylis-Hillman reaction

被引：105

作者：

Shi, M ^{[1
]}

Jiang, JK ^{[1
]}

Feng, YS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 16期

关键词：

D O I：

10.1021/ol000046x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] In the Baylis-Hillman reaction, we found that, when the reactions of arylaldehydes with methyl vinyl ketone were carried out at <-20 degrees C using a catalytic amount of amine as a Lewis base in the presence of titanium(IV) chloride, the chlorinated compounds 1 could be obtained as the major product in very high yields for various arylaldehydes. In addition, acrylonitrile could undergo the same reaction to give the corresponding chlorinated product in moderate yield.

引用

页码：2397 / 2400

页数：4

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