Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin

被引:78
作者
Lu, Jianming [1 ]
Tan, Xianghui [1 ]
Chen, Chuo [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA
关键词
D O I
10.1021/ja072844p
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)(2)/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method.
引用
收藏
页码:7768 / +
页数:3
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