Mitochondriomics or what makes us breathe

被引：105

作者：

Reichert, AS ^{[1
]}

Neupert, W ^{[1
]}

机构：

[1] Univ Munich, Adolf Butenandt Physiol Chem, D-81377 Munich, Germany

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 11期

关键词：

D O I：

10.1016/j.tig.2004.08.012

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mitochondria perform several fundamental cellular processes in higher eukaryotes including oxidative phosphorylation, Fe/S cluster formation and apoptosis. Dysfunction of the organelle is associated with a wide range of human diseases. To gain a better understanding of mitochondrial function, several recent proteomic, genetic, transcriptomic and bioinformatic approaches have set out to determine the complete set of mitochondrially located proteins in yeast, plants and mammals. Here, we review these studies and discuss the advances and limitations of individual strategies. Integration of various approaches proves to be a successful and useful way to identify the mitochondrial proteome with high sensitivity and specificity. The most comprehensive dataset is available for Saccharomyces cerevisiae, giving an estimated number of 700 different proteins located in mitochondria.

引用

页码：555 / 562

页数：8

共 59 条

[41] Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria [J].

Rothbauer, U ;

Hofmann, S ;

Mühlenbein, N ;

Paschen, SA ;

Gerbitz, KD ;

Neupert, W ;

Brunner, M ;

Bauer, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) :37327-37334

[42] MITOP, the mitochondrial proteome database: 2000 update [J].

Scharfe, C ;

Zaccaria, P ;

Hoertnagel, K ;

Jaksch, M ;

Klopstock, T ;

Dembowski, M ;

Lill, R ;

Prokisch, H ;

Gerbitz, KD ;

Neupert, W ;

Mewes, HW ;

Meitinger, T .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :155-158

[43] Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane [J].

Sesaki, H ;

Southard, SM ;

Yaffe, MP ;

Jensen, RE .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (06) :2342-2356

[44] Mitochondrial dynamics and division in budding yeast [J].

Shaw, JM ;

Nunnari, J .

TRENDS IN CELL BIOLOGY, 2002, 12 (04) :178-184

[45] The proteome of Saccharomyces cerevisiae mitochondria [J].

Sickmann, A ;

Reinders, J ;

Wagner, Y ;

Joppich, C ;

Zahedi, R ;

Meyer, HE ;

Schönfisch, B ;

Perschil, I ;

Chacinska, A ;

Guiard, B ;

Rehling, P ;

Pfanner, N ;

Meisinger, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13207-13212

[46] Predotar:: A tool for rapidly screening proteomes for N-terminal targeting sequences [J].

Small, I ;

Peeters, N ;

Legeai, F ;

Lurin, C .

PROTEOMICS, 2004, 4 (06) :1581-1590

[47] Systematic screen for human disease genes in yeast [J].

Steinmetz, LM ;

Scharfe, C ;

Deutschbauer, AM ;

Mokranjac, D ;

Herman, ZS ;

Jones, T ;

Chu, AM ;

Giaever, G ;

Prokisch, H ;

Oefner, PJ ;

Davis, RW .

NATURE GENETICS, 2002, 31 (04) :400-404

[48] Characterization of the human heart mitochondrial proteome [J].

Taylor, SW ;

Fahy, E ;

Zhang, B ;

Glenn, GM ;

Warnock, DE ;

Wiley, S ;

Murphy, AN ;

Gaucher, SP ;

Capaldi, RA ;

Gibson, BW ;

Ghosh, SS .

NATURE BIOTECHNOLOGY, 2003, 21 (03) :281-286

[49] Global organellar proteomics [J].

Taylor, SW ;

Fahy, E ;

Ghosh, SS .

TRENDS IN BIOTECHNOLOGY, 2003, 21 (02) :82-88

[50] An alternative strategy to determine the mitochondrial proteome using sucrose gradient fractionation and 1D PAGE on highly purified human heart mitochondria [J].

Taylor, SW ;

Warnock, DE ;

Glenn, GM ;

Zhang, B ;

Fahy, E ;

Gaucher, SP ;

Capaldi, RA ;

Gibson, BW ;

Ghosh, SS .

JOURNAL OF PROTEOME RESEARCH, 2002, 1 (05) :451-458

← 1 2 3 4 5 6 →