Amphiphilic α-helical antimicrobial peptides and their structure/function relationships

被引：158

作者：

Dennison, SR

Wallace, J

Harris, F

Phoenix, DA ^{[1
]}

机构：

[1] Univ Cent Lancashire, Fac Sci, Deans Off, Preston PR1 2HE, Lancs, England

[2] Univ Cent Lancashire, Dept Forens & Investigat Sci, Preston PR1 2HE, Lancs, England

[3] Univ Cent Lancashire, Dept Phys Math & Astron, Preston PR1 2HE, Lancs, England

来源：

PROTEIN AND PEPTIDE LETTERS | 2005年 / 12卷 / 01期

关键词：

D O I：

10.2174/0929866053406084

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To facilitate microbial membrane invasion, amphiphilic alpha-helical antimicrobial peptides (alpha-AMPs) show a spatial segregation of hydrophobic and hydrophilic residues about the alpha-helical long axis. Here we discuss potential mechanisms by which these peptides are able to disrupt membrane structure and the structural characteristics, which are required for function.

引用

收藏

页码：31 / 39

页数：9

相关论文

共 62 条

[21] Peptide antibiotics [J].

Hancock, REW .

LANCET, 1997, 349 (9049) :418-422

[22]

Harris F, 2000, MOL MEMBR BIOL, V17, P201

[23] Folding of amphipathic α-helices on membranes:: Energetics of helix formation by melittin [J].

Ladokhin, AS ;

White, SH .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 285 (04) :1363-1369

[24] PORE-FORMING PEPTIDE OF PATHOGENIC ENTAMOEBA-HISTOLYTICA [J].

LEIPPE, M ;

EBEL, S ;

SCHOENBERGER, OL ;

HORSTMANN, RD ;

MULLEREBERHARD, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7659-7663

[25] Structure-function relationships of temporins, small antimicrobialpeptides from amphibian skin [J].

Mangoni, ML ;

Rinaldi, AC ;

Di Giulio, A ;

Mignogna, G ;

Bozzi, A ;

Barra, D ;

Simmaco, M .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (05) :1447-1454

[26]

Marshall SH, 2003, ELECTRON J BIOTECHN, V6, P271

[27] DEFENSINS AND OTHER ENDOGENOUS PEPTIDE ANTIBIOTICS OF VERTEBRATES [J].

MARTIN, E ;

GANZ, T ;

LEHRER, RI .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (02) :128-136

[28] Rapid sequence divergence in mammalian β-defensins by adaptive evolution [J].

Maxwell, AI ;

Morrison, GM ;

Dorin, JR .

MOLECULAR IMMUNOLOGY, 2003, 40 (07) :413-421

[29] OLIGOPEPTIDE BIASES IN PROTEIN SEQUENCES AND THEIR USE IN PREDICTING PROTEIN CODING REGIONS IN NUCLEOTIDE-SEQUENCES [J].

MCCALDON, P ;

ARGOS, P .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1988, 4 (02) :99-122

[30] Design of gram-negative selective antimicrobial peptides [J].

Muhle, SA ;

Tam, JP .

BIOCHEMISTRY, 2001, 40 (19) :5777-5785

← 1 2 3 4 5 6 7 →