共 197 条
Genetics of hypertension: from experimental models to clinical applications
被引:29
作者:

Lee, WK
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Dept Med & Therapeut, BHF,Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow, Western Infirm, Dept Med & Therapeut, BHF,Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland

论文数: 引用数:
h-index:
机构:

Dominiczak, AF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Dept Med & Therapeut, BHF,Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow, Western Infirm, Dept Med & Therapeut, BHF,Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland
机构:
[1] Univ Glasgow, Western Infirm, Dept Med & Therapeut, BHF,Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland
基金:
英国医学研究理事会;
关键词:
quantitative trait loci;
essential hypertension;
congenic strains;
linkage analysis;
candidate genes;
monogenic hypertension;
D O I:
10.1038/sj.jhh.1001043
中图分类号:
R6 [外科学];
学科分类号:
1002 ;
100210 ;
摘要:
Human essential hypertension is a complex, multifactorial, quantitative trait under a polygenic control. Over the last decade several strategies have been used to dissect the genetic determinants of hypertension. Of these strategies, the study of rare monogenic forms of hypertension has been the most successful. Attempts to identify the multiple genes involved in the more common polygenic form of hypertension has been more difficult. Many laboratories use rat models of genetic hypertension where some of the complexity of studying human hypertension can be removed. Numerous crosses between hypertensive and normotensive strains have produced several quantitative trait loci (QTL) for blood pressure and other related phenotypes such as left ventricular hypertrophy, stroke, insulin resistance and kidney failure. In this review we describe established and novel strategies to dissect the susceptibility and severity loci for human essential hypertension. We also illustrate a few successful examples of a direct translation of genetic discoveries from the experimental setting to human investigation. The use of new molecular tools such as gene 'chips' or microarrays for either gene expression profiling or single nucleotide polymorphisms (SNPs)-based total genome scanning strategies will ultimately result in new diagnostics and therapeutics for human essential hypertension.
引用
收藏
页码:631 / 647
页数:17
相关论文
共 197 条
[81]
Independent genetic susceptibility to cardiac hypertrophy in inherited hypertension
[J].
Innes, BA
;
McLaughlin, MG
;
Kapuscinski, MK
;
Jacob, HJ
;
Harrap, SB
.
HYPERTENSION,
1998, 31 (03)
:741-746

Innes, BA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia

McLaughlin, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia

Kapuscinski, MK
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia

Jacob, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia

Harrap, SB
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia Univ Melbourne, Dept Physiol, Parkville, Vic 3052, Australia
[82]
No association between α-adducin 460 polymorphism and essential hypertension in a Japanese population
[J].
Ishikawa, K
;
Katsuya, T
;
Sato, N
;
Nakata, Y
;
Takami, S
;
Takiuchi, S
;
Fu, YX
;
Higaki, J
;
Ogihara, T
.
AMERICAN JOURNAL OF HYPERTENSION,
1998, 11 (04)
:502-506

Ishikawa, K
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Katsuya, T
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Sato, N
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Nakata, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Takami, S
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Takiuchi, S
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Fu, YX
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Higaki, J
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan

Ogihara, T
论文数: 0 引用数: 0
h-index: 0
机构:
Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan Osaka Univ, Sch Med, Dept Geriatr Med, Osaka 553, Japan
[83]
Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity
[J].
Iwai, N
;
Tsujita, Y
;
Kinoshita, M
.
HYPERTENSION,
1998, 32 (04)
:636-638

Iwai, N
论文数: 0 引用数: 0
h-index: 0
机构:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 52021, Japan Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 52021, Japan

论文数: 引用数:
h-index:
机构:

Kinoshita, M
论文数: 0 引用数: 0
h-index: 0
机构:
Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 52021, Japan Shiga Univ Med Sci, Dept Internal Med 1, Otsu, Shiga 52021, Japan
[84]
GENETIC-MAPPING OF A GENE CAUSING HYPERTENSION IN THE STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RAT
[J].
JACOB, HJ
;
LINDPAINTNER, K
;
LINCOLN, SE
;
KUSUMI, K
;
BUNKER, RK
;
MAO, YP
;
GANTEN, D
;
DZAU, VJ
;
LANDER, ES
.
CELL,
1991, 67 (01)
:213-224

JACOB, HJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

LINDPAINTNER, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

LINCOLN, SE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

论文数: 引用数:
h-index:
机构:

BUNKER, RK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

MAO, YP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

GANTEN, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

DZAU, VJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY

LANDER, ES
论文数: 0 引用数: 0
h-index: 0
机构: UNIV HEIDELBERG, GERMAN INST HIGH BLOOD PRESSURE RES, W-6900 HEIDELBERG, GERMANY
[85]
A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS
[J].
JACOB, HJ
;
BROWN, DM
;
BUNKER, RK
;
DALY, MJ
;
DZAU, VJ
;
GOODMAN, A
;
KOIKE, G
;
KREN, V
;
KURTZ, T
;
LERNMARK, A
;
LEVAN, G
;
MAO, YP
;
PETTERSSON, A
;
PRAVENEC, M
;
SIMON, JS
;
SZPIRER, C
;
SZPIRER, J
;
TROLLIET, MR
;
WINER, ES
;
LANDER, ES
.
NATURE GENETICS,
1995, 9 (01)
:63-69

JACOB, HJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

BROWN, DM
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

BUNKER, RK
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

DALY, MJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

DZAU, VJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

GOODMAN, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

KOIKE, G
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

KREN, V
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

KURTZ, T
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

LERNMARK, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

LEVAN, G
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

MAO, YP
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

PETTERSSON, A
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

PRAVENEC, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

SIMON, JS
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

SZPIRER, C
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

SZPIRER, J
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

TROLLIET, MR
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

WINER, ES
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA

LANDER, ES
论文数: 0 引用数: 0
h-index: 0
机构: MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA USA
[86]
825T allele of the G-protein β3 subunit gene (GNB3) is associated with impaired left ventricular diastolic filling in essential hypertension
[J].
Jacobi, J
;
Hilgers, KF
;
Schlaich, MP
;
Siffert, W
;
Schmieder, RE
.
JOURNAL OF HYPERTENSION,
1999, 17 (10)
:1457-1462

Jacobi, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Med Klin 44, Dept Med Nephrol, D-90471 Nurnberg, Germany

Hilgers, KF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Med Klin 44, Dept Med Nephrol, D-90471 Nurnberg, Germany

Schlaich, MP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Med Klin 44, Dept Med Nephrol, D-90471 Nurnberg, Germany

Siffert, W
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Med Klin 44, Dept Med Nephrol, D-90471 Nurnberg, Germany

Schmieder, RE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Erlangen Nurnberg, Med Klin 44, Dept Med Nephrol, D-90471 Nurnberg, Germany
[87]
GLUCOCORTICOID-SUPPRESSIBLE HYPERALDOSTERONISM - EFFECTS OF CROSSOVER SITE AND PARENTAL ORIGIN OF CHIMERIC GENE ON PHENOTYPIC-EXPRESSION
[J].
JAMIESON, A
;
SLUTSKER, L
;
INGLIS, GC
;
FRASER, R
;
WHITE, PC
;
CONNELL, JMC
.
CLINICAL SCIENCE,
1995, 88 (05)
:563-570

JAMIESON, A
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND

SLUTSKER, L
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND

INGLIS, GC
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND

FRASER, R
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND

WHITE, PC
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND

CONNELL, JMC
论文数: 0 引用数: 0
h-index: 0
机构: WESTERN INFIRM & ASSOCIATED HOSP,MRC,BLOOD PRESSURE GRP,GLASGOW G11 6NT,LANARK,SCOTLAND
[88]
Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2
[J].
Jeffs, B
;
Negrin, CD
;
Graham, D
;
Clark, JS
;
Anderson, NH
;
Gauguier, D
;
Dominiczak, AF
.
HYPERTENSION,
2000, 35 (01)
:179-187

Jeffs, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Negrin, CD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Graham, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Clark, JS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Anderson, NH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Gauguier, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland

Dominiczak, AF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland Univ Glasgow, Western Infirm, Dept Med & Therapeut, Glasgow G11 6NT, Lanark, Scotland
[89]
Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus
[J].
Jeffs, B
;
Clark, JS
;
Anderson, NH
;
Gratton, J
;
Brosnan, MJ
;
Gauguier, D
;
Reid, JL
;
Macrae, IM
;
Dominiczak, AF
.
NATURE GENETICS,
1997, 16 (04)
:364-367

Jeffs, B
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Clark, JS
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Anderson, NH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Gratton, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Brosnan, MJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Gauguier, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Reid, JL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Macrae, IM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND

Dominiczak, AF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV GLASGOW, WESTERN INFIRM,DEPT MED & THERAPEUT, GLASGOW G11 6NT, LANARK, SCOTLAND
[90]
Haplotypes of angiotensinogen in essential hypertension
[J].
Jeunemaitre, X
;
Inoue, I
;
Williams, C
;
Charru, A
;
Tichet, J
;
Powers, M
;
Sharma, AM
;
GimenezRoqueplo, AP
;
Hata, A
;
Corvol, P
;
Lalouel, JM
.
AMERICAN JOURNAL OF HUMAN GENETICS,
1997, 60 (06)
:1448-1460

Jeunemaitre, X
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Inoue, I
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

论文数: 引用数:
h-index:
机构:

Charru, A
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Tichet, J
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Powers, M
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Sharma, AM
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

GimenezRoqueplo, AP
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Hata, A
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Corvol, P
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE

Lalouel, JM
论文数: 0 引用数: 0
h-index: 0
机构: COLL FRANCE,INSERM U36,F-75231 PARIS,FRANCE