Host factors exploited by retroviruses

被引：206

作者：

Goff, Stephen P.

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[2] Columbia Univ Coll Phys & Surg, Dept Microbiol, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2007年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrmicro1541

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Retroviruses make a long and complex journey from outside the cell to the nucleus in the early stages of infection, and then an equally long journey back out again in the late stages of infection. Ongoing efforts are identifying an enormous array of cellular proteins that are used by the viruses in the course of their travels. These host factors are potential new targets for therapeutic intervention.

引用

收藏

页码：253 / 263

页数：11

相关论文

共 177 条

[81] The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes [J].

Lin, CW ;

Engelman, A .

JOURNAL OF VIROLOGY, 2003, 77 (08) :5030-5036

[82] Multimerization of human immunodeficiency virus type 1 gag promotes its localization to barges, raft-like membrane microdomains [J].

Lindwasser, OW ;

Resh, MD .

JOURNAL OF VIROLOGY, 2001, 75 (17) :7913-7924

[83] Basic residues in the nucleocapsid domain of gag are required for interaction of HIV-1 Gag with ABCE1 (HP68), a cellular protein important for HIV-1 capsid assembly [J].

Lingappa, JR ;

Dooher, JE ;

Newman, MA ;

Kiser, PK ;

Klein, KC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (07) :3773-3784

[84] Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase [J].

Llano, M ;

Delgado, S ;

Vanegas, M ;

Poeschla, EM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (53) :55570-55577

[85] LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes [J].

Llano, M ;

Vanegas, M ;

Fregoso, O ;

Saenz, D ;

Chung, S ;

Peretz, M ;

Poeschla, EM .

JOURNAL OF VIROLOGY, 2004, 78 (17) :9524-9537

[86] An essential role for LEDGF/p75 in HIV integration [J].

Llano, Manuel ;

Saenz, Dyana T. ;

Meehan, Anne ;

Wongthida, Phonphimon ;

Peretz, Mary ;

Walker, William H. ;

Teo, Wulin ;

Poeschla, Eric M. .

SCIENCE, 2006, 314 (5798) :461-464

[87] The membrane-proximal intracytoplasmic tyrosine residue of HIV-1 envelope glycoprotein is critical for basolateral targeting of viral budding in MDCK cells [J].

Lodge, R ;

Lalonde, JP ;

Lemay, G ;

Cohen, EA .

EMBO JOURNAL, 1997, 16 (04) :695-705

[88] Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions [J].

Lopez-Verges, Sandra ;

Camus, Gregory ;

Blot, Guillaume ;

Beauvoir, Roxane ;

Benarous, Richard ;

Berlioz-Torrent, Clarisse .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) :14947-14952

[89] Characterization of an internal ribosomal entry segment within the 5' leader of avian reticuloendotheliosis virus type a RNA and development of novel MLV-REV-based retroviral vectors [J].

LopezLastra, M ;

Gabus, C ;

Darlix, JL .

HUMAN GENE THERAPY, 1997, 8 (16) :1855-1865

[90] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GAG PROTEIN BINDS TO CYCLOPHILIN-A AND CYCLOPHILIN-B [J].

LUBAN, J ;

BOSSOLT, KL ;

FRANKE, EK ;

KALPANA, GV ;

GOFF, SP .

CELL, 1993, 73 (06) :1067-1078

← 4 5 6 7 8 9 10 11 12 13 →