A highly active 4-siloxyproline catalyst for asymmetric synthesis

被引：120

作者：

Hayashi, Y ^{[1
]}

Yamaguchi, J

Hibino, K

Sumiya, T

Urushima, T

Shoji, M

Hashizume, D

Koshino, H

机构：

[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan

[2] RIKEN, Wako, Saitama 3510198, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2004年 / 346卷 / 12期

关键词：

asymmetric synthesis; Mannich reaction; organic catalysis; oxidation; proline;

D O I：

10.1002/adsc.200404166

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

trans-4-tert-Butyldimethylsiloxy-L-proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the alpha-aminoxylation of carbonyl compounds, as well as O-nitrosoaldol/Michael, and Mannich reactions.

引用

页码：1435 / 1439

页数：5