共 71 条
A highly active 4-siloxyproline catalyst for asymmetric synthesis
被引:120
作者:
Hayashi, Y
[1
]
Yamaguchi, J
Hibino, K
Sumiya, T
Urushima, T
Shoji, M
Hashizume, D
Koshino, H
机构:
[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan
[2] RIKEN, Wako, Saitama 3510198, Japan
关键词:
asymmetric synthesis;
Mannich reaction;
organic catalysis;
oxidation;
proline;
D O I:
10.1002/adsc.200404166
中图分类号:
O69 [应用化学];
学科分类号:
081704 ;
摘要:
trans-4-tert-Butyldimethylsiloxy-L-proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the alpha-aminoxylation of carbonyl compounds, as well as O-nitrosoaldol/Michael, and Mannich reactions.
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页码:1435 / 1439
页数:5
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