A highly active 4-siloxyproline catalyst for asymmetric synthesis

被引:120
作者
Hayashi, Y [1 ]
Yamaguchi, J
Hibino, K
Sumiya, T
Urushima, T
Shoji, M
Hashizume, D
Koshino, H
机构
[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan
[2] RIKEN, Wako, Saitama 3510198, Japan
关键词
asymmetric synthesis; Mannich reaction; organic catalysis; oxidation; proline;
D O I
10.1002/adsc.200404166
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
trans-4-tert-Butyldimethylsiloxy-L-proline displays a greater catalytic activity than the parent proline without compromising the enantioselectivity, which widens the substrate scope in the alpha-aminoxylation of carbonyl compounds, as well as O-nitrosoaldol/Michael, and Mannich reactions.
引用
收藏
页码:1435 / 1439
页数:5
相关论文
共 71 条