Macrophage Diversity Enhances Tumor Progression and Metastasis

被引：4200

作者：

Qian, Bin-Zhi ^{[1
]}

Pollard, Jeffrey W. ^{[1
,2
,3
]}

机构：

[1] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Cooperat Ctr Study Reprod & Infertil Res, Bronx, NY 10461 USA

来源：

CELL | 2010年 / 141卷 / 01期

基金：

美国国家卫生研究院;

关键词：

COLONY-STIMULATING FACTOR; ENDOTHELIAL GROWTH-FACTOR; NF-KAPPA-B; MONOCYTE CHEMOATTRACTANT PROTEIN-1; GENE-EXPRESSION ANALYSIS; LYMPH-NODE METASTASIS; MYELOID CELLS; PROMOTE TUMOR; MOUSE MODEL; ANGIOGENIC SWITCH;

D O I：

10.1016/j.cell.2010.03.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation, they create an inflammatory environment that is mutagenic and promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration and invasion, and suppress antitumor immunity. At metastatic sites, macrophages prepare the target tissue for arrival of tumor cells, and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.

引用

页码：39 / 51

页数：13

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