Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor

被引：50

作者：

Schmink, Jason R. ^{[1
]}

Kormos, Chad M. ^{[1
]}

Devine, William G. ^{[1
]}

Leadbeater, Nicholas E. ^{[1
]}

机构：

[1] Univ Connecticut, Dept Chem, Storrs, CT 06269 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 01期

基金：

美国国家科学基金会;

关键词：

ASSISTED SYNTHESIS; PROMOTED REACTIONS; HEATING ELEMENTS; SOLVENT-FREE; VESSEL; OPTIMIZATION; SUZUKI; IRRADIATION; INHIBITOR; APPARATUS;

D O I：

10.1021/op900287j

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1-1 nmol) to large (1-18 mol) runs.

引用

页码：205 / 214

页数：10

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