APOBEC-mediated viral restriction: not simply editing?

被引：222

作者：

Holmes, Rebecca K. ^{[1
]}

Malim, Michael H. ^{[1
]}

Bishop, Kate N. ^{[1
]}

机构：

[1] Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tibs.2007.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The APOBEC family of cytidine deaminases inhibit the mobility of diverse retroviruses, retrotransposons and other viruses. Initial reports proposed that these effects were due to the DNA editing capabilities of these enzymes; however, many recent studies have provided evidence suggesting that APOBEC proteins can inhibit these elements by several mechanisms, including editing-dependent and editing-independent processes. Investigating these modes of action and the potential contribution that each one makes to the antiviral activities of various APOBEC proteins is vital if we are to understand how APOBEC proteins protect host genomes from invading nucleic acids.

引用

页码：118 / 128

页数：11

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