APOBEC-mediated viral restriction: not simply editing?

被引：222

作者：

Holmes, Rebecca K. ^{[1
]}

Malim, Michael H. ^{[1
]}

Bishop, Kate N. ^{[1
]}

机构：

[1] Kings Coll London, Sch Med, Dept Infect Dis, London SE1 9RT, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tibs.2007.01.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The APOBEC family of cytidine deaminases inhibit the mobility of diverse retroviruses, retrotransposons and other viruses. Initial reports proposed that these effects were due to the DNA editing capabilities of these enzymes; however, many recent studies have provided evidence suggesting that APOBEC proteins can inhibit these elements by several mechanisms, including editing-dependent and editing-independent processes. Investigating these modes of action and the potential contribution that each one makes to the antiviral activities of various APOBEC proteins is vital if we are to understand how APOBEC proteins protect host genomes from invading nucleic acids.

引用

页码：118 / 128

页数：11

共 105 条

[61] Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme [J].

Muramatsu, M ;

Kinoshita, K ;

Fagarasan, S ;

Yamada, S ;

Shinkai, Y ;

Honjo, T .

CELL, 2000, 102 (05) :553-563

[62] ALTERNATIVE MESSENGER-RNA SPLICING AND DIFFERENTIAL PROMOTER UTILIZATION DETERMINE TISSUE-SPECIFIC EXPRESSION OF THE APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN (APOBEC1) GENE IN MICE - STRUCTURE AND EVOLUTION OF APOBEC1 AND RELATED NUCLEOSIDE NUCLEOTIDE DEAMINASES [J].

NAKAMUTA, M ;

OKA, K ;

KRUSHKAL, J ;

KOBAYASHI, K ;

YAMAMOTO, M ;

LI, WH ;

CHAN, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :13042-13056

[63]

NAVARATNAM N, 1993, J BIOL CHEM, V268, P20709

[64] Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity [J].

Newman, ENC ;

Holmes, RK ;

Craig, HM ;

Klein, KC ;

Lingappa, JR ;

Malim, MH ;

Sheehy, AM .

CURRENT BIOLOGY, 2005, 15 (02) :166-170

[65] G to A hypermutation of hepatitis B virus [J].

Noguchi, C ;

Ishino, H ;

Tsuge, M ;

Fujimoto, Y ;

Imamura, M ;

Takahashi, S ;

Chayama, K .

HEPATOLOGY, 2005, 41 (03) :626-633

[66] The AID enzyme induces class switch recombination in fibroblasts [J].

Okazaki, IM ;

Kinoshita, K ;

Muramatsu, M ;

Yoshikawa, K ;

Honjo, T .

NATURE, 2002, 416 (6878) :340-345

[67] Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the hyper-IgM syndrome (HIGM2) [J].

Revy, P ;

Muto, T ;

Levy, Y ;

Geissmann, F ;

Plebani, A ;

Sanal, O ;

Catalan, N ;

Forveille, M ;

Dufourcq-Lagelouse, R ;

Gennery, A ;

Tezcan, I ;

Ersoy, F ;

Kayserili, H ;

Ugazio, AG ;

Brousse, N ;

Muramatsu, M ;

Notarangelo, LD ;

Kinoshita, K ;

Honjo, T ;

Fischer, A ;

Durandy, A .

CELL, 2000, 102 (05) :565-575

[68] Functional analysis of vif protein shows less restriction of human immunodeficiency virus type 2 by APOBEC3G [J].

Ribeiro, AC ;

Silva, AME ;

Santa-Marta, M ;

Pombo, A ;

Moniz-Pereira, J ;

Goncalves, J ;

Barahona, I .

JOURNAL OF VIROLOGY, 2005, 79 (02) :823-833

[69] Regulated production and anti-HIV type 1 activities of cytidine deaminases APOBEC3B, 3F, and 3G [J].

Rose, KM ;

Marin, M ;

Kozak, SL ;

Kabat, D .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2005, 21 (07) :611-619

[70] APOBEC-mediated interference with hepadnavirus production [J].

Rösler, C ;

Köck, J ;

Kann, M ;

Malim, MH ;

Blum, HE ;

Baumert, TF ;

von Weizsäcker, F .

HEPATOLOGY, 2005, 42 (02) :301-309

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