Resveratrol and Alzheimer's Disease: Mechanistic Insights

被引：156

作者：

Ahmed, Touqeer ^{[1
]}

Javed, Sehrish ^{[1
]}

Javed, Sana ^{[1
]}

Tariq, Ameema ^{[1
]}

Samec, Dunja ^{[2
]}

Tejada, Silvia ^{[3
]}

Nabavi, Seyed Fazel ^{[4
]}

Braidy, Nady ^{[5
]}

Nabavi, Seyed Mohammad ^{[4
]}

机构：

[1] Natl Univ Sci & Technol, Atta Ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Neurobiol Lab, Sect H-12, Islamabad 44000, Pakistan

[2] Inst Ruder Boskovic, Dept Mol Biol, Bijenicka C 54,POB 180, Zagreb 10000, Croatia

[3] IUNICS, Son Llatzer Hosp, Res Unit, Expt Lab, Ctra Manacor Km 4, Palma De Mallorca 07198, Balearic Island, Spain

[4] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran

[5] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

来源：

MOLECULAR NEUROBIOLOGY | 2017年 / 54卷 / 04期

关键词：

Alzheimer's disease; Resveratrol; Amyloid; Neurodegeneration; Neuroinflammation; BLOOD-BRAIN-BARRIER; TRANS-RESVERATROL; OXIDATIVE STRESS; BIOLOGICAL EVALUATION; RED WINE; A-BETA; LIQUID-CHROMATOGRAPHY; MICROGLIAL ACTIVATION; CEREBRAL-ISCHEMIA; EPSILON-VINIFERIN;

D O I：

10.1007/s12035-016-9839-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Alzheimer's disease (AD) is the leading cause of dementia in the elderly and is characterized by progressive cognitive and memory deficits. The pathological hallmarks of AD include extracellular senile plaques and intracellular neurofibrillary tangles. Although several mechanisms have been used to explain the underlying pathogenesis of AD, current treatment regimens remain inadequate. The neuroprotective effects of the polyphenolic stilbene resveratrol (3,5,4'-trihydroxy-trans-stilbene) have been investigated in several in vitro and in vivo models of AD. The current review discusses the multiple potential mechanisms of action of resveratrol on the pathobiology of AD. Moreover, due to the limited pharmacokinetic parameters of resveratrol, multiple strategies aimed at increasing the bioavailability of resveratrol have also been addressed.

引用

页码：2622 / 2635

页数：14

共 154 条

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Physicochemical Characteristics, Functional Properties, and Nutritional Benefits of Peanut Oil: A Review [J].