Human serum amyloid A protein inhibits hepatitis C virus entry into cells

被引：62

作者：

Cai, Zhaohui

Cai, Lei

Jiang, Jieyun

Chang, Kyung-Soo

van der Westhuyzen, Deneys R.

Luo, Guangxiang

机构：

[1] Univ Kentucky, Coll Med, Dept Microbiol, Lexington, KY 40536 USA

[2] Univ Kentucky, Coll Med, Dept Immunol, Lexington, KY 40536 USA

[3] Univ Kentucky, Coll Med, Dept Mol Genet, Lexington, KY 40536 USA

[4] Univ Kentucky, Coll Med, Dept Internal Med, Lexington, KY 40536 USA

[5] Univ Kentucky, Coll Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA

[6] Univ Kentucky, Coll Med, Grad Ctr Nutr Sci, Lexington, KY 40536 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 11期

关键词：

D O I：

10.1128/JVI.02627-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.

引用

页码：6128 / 6133

页数：6