Promiscuity and the single receptor: NKG2D

被引：297

作者：

Eagle, Robert A. ^{[1
]}

Trowsdale, John ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge Int Med Res, Addenbrookes Hosp, Cambridge CB2 OXY, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 09期

关键词：

MHC-CLASS-I; CELL-MEDIATED REJECTION; NATURAL-KILLER-CELLS; HUMAN NK CELLS; HUMAN CYTOMEGALOVIRUS; T-CELLS; UL16-BINDING PROTEIN; DOWN-REGULATION; INTRACELLULAR RETENTION; SURFACE EXPRESSION;

D O I：

10.1038/nri2144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by natural killer (NK) cells and T cells that regulates immune responses during infection, cancer and autoimmunity. NKG2D ligands comprise a diverse array of MHC-class- I- related proteins that are upregulated by cellular stress. Why is it beneficial for the host to have so many ligands for the same receptor? In this Opinion article, we propose that although competition with viruses is the most likely evolutionary drive for this diversity, there might be other explanations.

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页码：737 / 744

页数：8

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