The microRNA network and tumor metastasis

被引：163

作者：

Zhang, H. ^{[1
]}

Li, Y. ^{[1
]}

Lai, M. ^{[1
]}

机构：

[1] Zhejiang Univ, Sch Med, Dept Pathol, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ONCOGENE | 2010年 / 29卷 / 07期

关键词：

microRNA; tumor; metastasis; BREAST-CANCER METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH-FACTOR RECEPTOR; SUPPRESSOR GENE; MIR-200; FAMILY; PROSTATE-CANCER; LUNG-CANCER; REDUCED EXPRESSION; MIRNA EXPRESSION; REPRESSORS ZEB1;

D O I：

10.1038/onc.2009.406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis is the most significant process affecting the clinical management of cancer patients and occurs in multiple sequential steps. However, the molecular pathways underlying each step still remain obscure. Recent research has shown that there is a microRNA (miRNA) network that functions as a regulator of tumor metastasis. In this paper, we review the role of miRNAs in tumor metastasis, including control of epithelial-mesenchymal transition, regulation of metastasis-associated genes and epigenetic alterations. More information on miRNAs will promote a better understanding of the molecular mechanism of metastasis. Oncogene (2010) 29, 937-948; doi:10.1038/onc.2009.406; published online 23 November 2009

引用

页码：937 / 948

页数：12

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